diphyllin manufacturers
- Diphyllin
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- $38.00
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2026-07-27
- CAS:22055-22-7
- Purity: 99.91%
- Supply Ability: 10g
- diphyllin
-
-
2026-07-10
- CAS:22055-22-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | diphyllin Basic information |
| Product Name: | diphyllin | | Synonyms: | 4-Hydroxy-6,7-dimethoxy-9-(1,3-benzodioxole-5-yl)-1,3-dihydronaphtho[2,3-c]furan-1-one;9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one;Diphyllin【naphthofuran】;NSC 309691;Benz[f]isobenzofuran-1(3H)-one,9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-;Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-;Diphyllin >=98% (HPLC);Phyllis | | CAS: | 22055-22-7 | | MF: | C21H16O7 | | MW: | 380.35 | | EINECS: | | | Product Categories: | | | Mol File: | 22055-22-7.mol |  |
| | diphyllin Chemical Properties |
| Melting point | 290℃ (methanol ) | | Boiling point | 638.8±55.0 °C(Predicted) | | density | 1.445±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO | | pka | 7.82±0.20(Predicted) | | form | powder | | color | white to light brown | | InChI | InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3 | | InChIKey | VMEJANRODATDOF-UHFFFAOYSA-N | | SMILES | O1CC2=C(O)C3C(C(C4=CC=C5OCOC5=C4)=C2C1=O)=CC(OC)=C(OC)C=3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | diphyllin Usage And Synthesis |
| Chemical Properties | Pale yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the rhizomes of Sinopodophyllum hexandrum (Royle) Ying; Dysosma versipellis (Hance) M. Cheng ex Ying. | | Uses | Diphyllin has been used to study its antibacterial and antibiofilm activities against fish pathogens. | | Definition | ChEBI: Diphyllin is a lignan. | | General Description | Diphyllin, a major glycoside compound, is a plant-derived lignan. It is present in Cleistanthus collinus. | | Biochem/physiol Actions | Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities. It is a potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts. | | in vivo | Diphyllin (20 mg/kg; oral; once a day; for 10 consecutive days) significantly inhibits the tumor growth of SGC7901 cells in mice, reduced tumor weight, downregulated the expression of V-ATPase in tumor tissues, and reduced the levels of MMP-2 and MMP-9 in serum[4].
| | IC 50 | HIV-1: 0.38 μM (IC50); Vacuolar type H+-ATPase: 17 nM (IC50); Vesicular stomatitis virus (VSV) |
| | diphyllin Preparation Products And Raw materials |
| Raw materials | 2,3-Naphthalenedicarboxylic acid, 1-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-, 2,3-diethyl ester-->Naphtho[2,3-c]furan-1,4-dione, 9-(1,3-benzodioxol-5-yl)-3,3a,9,9a-tetrahydro-9-hydroxy-6,7-dimethoxy-, [3aS-(3aα,9α,9aα)]- (9CI)-->9-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl acetate-->6-Bromoveratraldehyde-->Diethyl ether | | Preparation Products | justicidin A |
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