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- Asterric Acid
-
- $535.00
-
2026-04-21
- CAS:577-64-0
- Purity:
- Supply Ability: 10g
|
| | asterric acid Basic information |
| Product Name: | asterric acid | | Synonyms: | asterric acid;2-(2-Methoxycarbonyl-4-hydroxy-6-methoxyphenoxy)-4-methyl-6-hydroxybenzoic acid;DiMethylosoic acid,TAN 1415A, WF 12880A;Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester;577-64-0
Asterric acid
Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester;577-64-0
Asterric acid
Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester | | CAS: | 577-64-0 | | MF: | C17H16O8 | | MW: | 348.3 | | EINECS: | | | Product Categories: | | | Mol File: | 577-64-0.mol |  |
| | asterric acid Chemical Properties |
| Melting point | 208-214 °C | | Boiling point | 557.6±50.0 °C(Predicted) | | density | 1.406±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide | | form | solid | | pka | 2.97±0.34(Predicted) | | color | white | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChI | 1S/C17H16O8/c1-8-4-11(19)14(16(20)21)12(5-8)25-15-10(17(22)24-3)6-9(18)7-13(15)23-2/h4-7,18-19H,1-3H3,(H,20,21) | | InChIKey | XOKVHFNTYHPEHN-UHFFFAOYSA-N | | SMILES | O(C)c1c(c(cc(c1)O)C(=O)OC)Oc2c(c(cc(c2)C)O)C(=O)O |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Acute 1
Aquatic Chronic 1 |
| | asterric acid Usage And Synthesis |
| Uses | Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells. | | Biological Activity | asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor. | | in vitro | previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1]. | | IC 50 | 10 μm for et-1 binding to the eta receptor ofa10 cells | | references | [1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992). |
| | asterric acid Preparation Products And Raw materials |
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