3-[(tert-Butyldimethylsilyl)oxy]-1-propanal

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3-[(tert-Butyldimethylsilyl)oxy]-1-propanal Basic information

Product Name:	3-[(tert-Butyldimethylsilyl)oxy]-1-propanal
Synonyms:	3-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-PROPIONALDEHYDE;3-Tert-butyldiMethylsilyloxy)propionaldehyde;3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]propanal;Propanal,3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-;3-(tert-Butyldimethylsiloxy)propionaldehyde;3-[Dimethyl(1,1-dimethylethyl)siloxy]propanal;3-tert-Butyldimethylsiloxy)propanal;3-tert-Butyldimethylsilyloxypropanal
CAS:	89922-82-7
MF:	C9H20O2Si
MW:	188.34
EINECS:
Product Categories:	Miscellaneous Reagents
Mol File:	89922-82-7.mol

3-[(tert-Butyldimethylsilyl)oxy]-1-propanal Chemical Properties

Boiling point	95 °C(Press: 23 Torr)
density	0.892 g/mL at 25 °C
refractive index	n20/D1.431
Fp	84℃
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Colourless to Pale Yellow
InChI	InChI=1S/C9H20O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h7H,6,8H2,1-5H3
InChIKey	WGWCJTNWUFFGFH-UHFFFAOYSA-N
SMILES	C(=O)CCO[Si](C(C)(C)C)(C)C

Safety Information

MSDS Information

3-[(tert-Butyldimethylsilyl)oxy]-1-propanal Usage And Synthesis

Chemical Properties	Brown Oil
Uses	3-[(tert-Butyldimethylsilyl)oxy]-1-propanal is useful for preparing EGFR inhibitors for the treatment of cancer.
Preparation	3-(tert-Butyldimethylsilyloxy)propanol (1.90 g, 10 mmol) was dissolved in dichloromethane (20 mL), and Dess-Martin reagent (6.36 g, 15 mmol) was added under ice bath. After stirring at room temperature for 4 hours, saturated aqueous sodium bicarbonate solution was added to quench, and the mixture was diluted with dichloromethane (100 mL). The mixture was washed twice with saturated aqueous sodium bicarbonate solution and once with brine. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The mixture was purified by silica gel column chromatography to obtain 1.55 g of 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal with a yield of 82%.
Chemical Reactivity	3-[(tert-Butyldimethylsilyl)oxy]-1-propanal is stable under normal conditions, it reacts with oxidizing agents.

3-[(tert-Butyldimethylsilyl)oxy]-1-propanal Preparation Products And Raw materials

Raw materials

Tag:3-[(tert-Butyldimethylsilyl)oxy]-1-propanal(89922-82-7) Related Product Information

Methyl (R)-(+)-3-(tert-butyldimethylsilyloxy)-5-oxo-1-cyclopentene-1-heptanoate Propionaldehyde Side chain for imipenem 3,5-Di-O-(tert-butyldimethylsilyl)-2-deoxy-D-ribonolactone (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one 3-(tert-Butyldimethylsilyloxy)glutaric anhydride 4-tert-Butyldimethylsilyloxy-2-diethylaminomethyl-2-cyclopentene-1-one Fmoc-Ser(bsi)-OH Fmoc-Thr(TBDMS)-OH 3'-O-(t-Butyldimethylsilyl)-5'-oxo-8,5'-cyclo-2'-deoxyadenosine Methyl (S)-(-)-4-bromo-3-tert-butyldimethylsilyloxybutanoate 3,6-Di-O-(tert-butyldimethylsilyl)-D-glucal N,N-Dibenzyl-O-(t-butyldimethylsilyl)-L-serine methyl ester (4S)-(-)-t-Butyldimethylsiloxy-2-cyclopenten-1-one (4R)-(+)-t-Butyldimethylsiloxy-2-cyclopenten-1-one 4-O-Acetyl-3,6-di-O-(tert-butyldimethylsilyl)-D-glucal 2-Methylidene-3-(R)-(3-(S)-t-butyldimethylsiloxy-oct-1-(E)-ene-1-yl)-4-(R)-t-butyl-dimethylsiloxy-cyclopentanone 2-Methylidene-3-(R)-(3-(S)-t-butyldimethylsiloxy-5-(S)-methyl-non-1-enyl)-4-(R)-t-butyl-dimethylsiloxy-cyclopentanone