|
|
| | ZANAPEZIL Basic information |
| Product Name: | ZANAPEZIL | | Synonyms: | ZANAPEZIL;1-Propanone, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-;TAK-147 free base;Zanapezil free base | | CAS: | 142852-50-4 | | MF: | C25H32N2O | | MW: | 376.53 | | EINECS: | | | Product Categories: | | | Mol File: | 142852-50-4.mol |  |
| | ZANAPEZIL Chemical Properties |
| form | Solid | | color | White to light yellow |
| | ZANAPEZIL Usage And Synthesis |
| Uses | Zanapezil is a acetylcholinesterase inhibitor that is a potential drug for treating Alzheimer disease. | | Definition | ChEBI: Zanapezil is a member of piperidines. | | in vivo | Oral administration of Zanapezil (TAK-147; 3 mg/kg) free base significantly accelerated the turnover rates of dopamine, noradrenaline and serotonin in the rat brain. Oral administration of Zanapezil free base at doses ranging from 1 to 10 mg/kg induces a statistically significant and dose-dependent decrease in AChE activity in the cerebral cortex in ex vivo experiments[1].
Zanapezil (TAK-147; 5 and 10 mg/kg) free base significantly increases ACh level in the ventral hippocampus (VH) for 120 min[2]. | Animal Model: | Male Wistar rats 7 weeks in age (230-240 g)[2] | | Dosage: | 5 and 10 mg/kg | | Administration: | Oral administration | | Result: | Increased acetylcholine (ACh) level in the VH for 120 min. |
| | IC 50 | AChE |
| | ZANAPEZIL Preparation Products And Raw materials |
|