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Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside

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Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside manufacturers
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Basic information
Product Name:Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
Synonyms:Pulsatilla saponin D (SB365);Pulsatilla Saponin D (90%);Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)-;Pulsatilla saponin D 68027-15-6;Pulsatilla saponin D, BR;Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)-;Hederagenin 3-O-α-L-rhamnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside;Pulsatilla saponin D, 10 mM in DMSO
CAS:68027-15-6
MF:C47H76O17
MW:913.09614
EINECS:211-708-6
Product Categories:reagent;standard substance;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:68027-15-6.mol
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Structure
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Chemical Properties
Melting point 239-241℃
Boiling point 997.6±65.0 °C(Predicted)
density 1.40±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Methanol (Slightly), Pyridine
pka4.63±0.70(Predicted)
form Solid
color White to Light Beige
Safety Information
MSDS Information
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Usage And Synthesis
DescriptionPulsatilla saponin D is an oleanane-type saponin that has been found in P. koreana and has anticancer activity. It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cells (EC50s = 11.25, 13.17, 3.04, and 11.86 μM, respectively). Pulsatilla saponin D (6 mg/kg per day) reduces tumor volume in a murine Lewis lung carcinoma model.
Chemical PropertiesWhite powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Pulsatilla chinensis.
UsesPulsatilla Saponin D shows antiangiogenic and antitumor activity.
DefinitionChEBI: Pulsatilla saponin D is a triterpenoid. It has a role as a metabolite.
in vivo

Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model[4].

Animal Model:2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice[4].
Dosage:6.4 mg/kg.
Administration:Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.
Result:Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).
References[1] SEONG-CHEOL BANG. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship.[J]. Chemical & pharmaceutical bulletin, 2005, 53 11: 1451-1454. DOI: 10.1248/cpb.53.1451
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Preparation Products And Raw materials
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N-Acetyllactosamine V Hederacolchiside E V Scabioside C Hederacolchiside A1 PULCHINENOSIDE B4 Lup-20(29)-en-28-oic acid, 3-[β-D-glucopyranosyl(1→4)[a-L-rhaMnopyranosyl) (1→2)-a -L-arabinopyranosyl]oxy], (3β,4a)-) Pulchinenoside B Anemoside A3 Pulchinenoside A3