Benzyl-PEG6-azide manufacturers
- Benzyl-PEG6-N3
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2025-06-07
- CAS:86770-73-2
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| | Benzyl-PEG6-azide Basic information |
| Product Name: | Benzyl-PEG6-azide | | Synonyms: | Benzyl-PEG6-azide;Benzyl-PEG6-N3;CAS_86770-73-2;2,5,8,11,14,17-Hexaoxanonadecane, 19-azido-1-phenyl-;19-Azido-1-phenyl-2,5,8,11,14,17-hexaoxanonadecane;19-Azido-1-phenyl-2,5,8,11,14,17-hexadecane;Benzyl-PEG6-azido | | CAS: | 86770-73-2 | | MF: | C19H31N3O6 | | MW: | 397.47 | | EINECS: | | | Product Categories: | | | Mol File: | 86770-73-2.mol |  |
| | Benzyl-PEG6-azide Chemical Properties |
| | Benzyl-PEG6-azide Usage And Synthesis |
| Uses | Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Benzyl-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | Biological Activity | Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Benzyl-PEG6-azide Preparation Products And Raw materials |
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