Tos-PEG5-CH2CO2t-butyl ester manufacturers
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| | Tos-PEG5-CH2CO2t-butyl ester Basic information |
| Product Name: | Tos-PEG5-CH2CO2t-butyl ester | | Synonyms: | Tos-PEG5-CH2CO2t-butyl ester;Tos-PEG4-CH2COOtBu;Tos-PEG5-CH2CO2tBu;Tos-PEG4-CH2-Boc;3,6,9,12-Tetraoxatetradecanoic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester;tert-butyl 2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]acetate;2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester;Tos-PEG4-t-butyl acetate | | CAS: | 169751-73-9 | | MF: | C21H34O9S | | MW: | 462.55 | | EINECS: | | | Product Categories: | | | Mol File: | 169751-73-9.mol |  |
| | Tos-PEG5-CH2CO2t-butyl ester Chemical Properties |
| Boiling point | 550.0±50.0 °C(Predicted) | | density | 1.163±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | Tos-PEG5-CH2CO2t-butyl ester Usage And Synthesis |
| Description | Tos-PEG5-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | | Uses | Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
| | Tos-PEG5-CH2CO2t-butyl ester Preparation Products And Raw materials |
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