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5-Bromo-2-chloro-4-picoline

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5-Bromo-2-chloro-4-picoline manufacturers
5-Bromo-2-chloro-4-picoline Basic information
Product Name:5-Bromo-2-chloro-4-picoline
Synonyms:5-BROMO-2-CHLORO-4-METHYL-PYRIDINE;5-Bromo-2-chloro-4-picoline, 98+%;2-CHLORO-4-METHYL-5-BROMOPYRIDINE;5-BroMo-2-chloro-4-picoline, 98+% 1GR;2-Chloro-5-bromo-4-methylpyridine;5-Bromo-2-chloro-4-methylpyridine>;Pyridine, 5-bromo-2-chloro-4-methyl-;2-Bromo-7-methylpyridine
CAS:778611-64-6
MF:C6H5BrClN
MW:206.47
EINECS:689-064-4
Product Categories:Variety of halogenated heterocyclic series;Boronic Acid;Pyridine series;blocks;Bromides;Pyridines;Pyridine
Mol File:778611-64-6.mol
5-Bromo-2-chloro-4-picoline Structure
5-Bromo-2-chloro-4-picoline Chemical Properties
Melting point 25-30 °C
Boiling point 239℃
density 1.624
refractive index 1.5400 (estimate)
Fp 99℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka-1.45±0.10(Predicted)
form powder to lump to clear liquid
color White or Colorless to Light yellow
InChIInChI=1S/C6H5BrClN/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3
InChIKeyISESOOISZHSENQ-UHFFFAOYSA-N
SMILESC1(Cl)=NC=C(Br)C(C)=C1
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-41-22-37/38
Safety Statements 37/39-26-39
WGK Germany 3
HazardClass IRRITANT
HS Code 29333990
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Dam. 1
MSDS Information
ProviderLanguage
ACROS English
5-Bromo-2-chloro-4-picoline Usage And Synthesis
Chemical PropertiesClear pale yellow low melting solid
Uses5-Bromo-2-chloro-4-methylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
SynthesisA solution of 2-chloro-5-bromopyridine (386 mg, 2 mmol) in THF (6 mL) was cooled to -78C and tert-butyl bromide (1.17 mL, 2 mmmol) was added dropwise under nitrogen. After 5 min at -78C, the brown solution was treated with a solution of the appropriate electrophilic reagent (3 mmol) in THF (4 mL). The reaction medium was then allowed to warm to room temperature (1 h) and the mixture was hydrolyzed with H2O (10 mL) at 0C. The aqueous layer was then extracted with Et2O. The organic layer (MgSO4) was dried and the solvent was evaporated under reduced pressure. The crude product was purified by column chromatography. Eluent: hexane-ethyl acetate (90:10). Compound - Chloro-4-methyl-5-bromopyridine in 50% yield.
5-Bromo-2-chloro-4-picoline Preparation Products And Raw materials
Preparation Products5-BroMo-4-(broMoMethyl)-2-chloropyridine
Tag:5-Bromo-2-chloro-4-picoline(778611-64-6) Related Product Information
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