Z-Asp-2,6-dichlorobenzoyloxymethylketone manufacturers
- Z-Asp-CH2-DCB
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2026-07-27
- CAS:153088-73-4
- Purity: 99.08%
- Supply Ability: 10g
- Z-Asp-CH2-DCB
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-
2026-07-23
- CAS:153088-73-4
- Purity: 99.08%
- Supply Ability: 10g
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| | Z-Asp-2,6-dichlorobenzoyloxymethylketone Basic information |
| | Z-Asp-2,6-dichlorobenzoyloxymethylketone Chemical Properties |
| Boiling point | 674.2±55.0 °C(Predicted) | | density | 1.440±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble in DMSO (up to 25 mg/ml). | | form | White to off-white powder. | | pka | 4.01±0.19(Predicted) | | color | white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | Z-Asp-2,6-dichlorobenzoyloxymethylketone Usage And Synthesis |
| Description | Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation. | | Uses | Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor. | | in vivo | Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis[1]. | Animal Model: | Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group)[1] | | Dosage: | 1 mg | | Administration: | Intraperitoneal injection; every day for 3 weeks | | Result: | The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity. |
| | References | [1] ROLAND E. DOLLE. P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme[J]. Journal of Medicinal Chemistry, 1994, 37 5: 563-564. DOI:10.1021/jm00031a003 |
| | Z-Asp-2,6-dichlorobenzoyloxymethylketone Preparation Products And Raw materials |
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