- PAC-1
-
- $43.00
-
2026-07-27
- CAS:315183-21-2
- Purity: 99.77%
- Supply Ability: 10g
|
| Product Name: | PAC1 | | Synonyms: | PAC1;4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide;PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide;PAC-1,PAC1;Procaspase activating coMpound 1;(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1 | | CAS: | 315183-21-2 | | MF: | C23H28N4O2 | | MW: | 392.49 | | EINECS: | | | Product Categories: | Inhibitor;Inhibitors | | Mol File: | 315183-21-2.mol |  |
| density | 1.14 | | storage temp. | Store at +4°C | | solubility | DMSO: ≥10mg/mL | | form | solid | | pka | 8.82±0.40(Predicted) | | color | white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months. | | InChI | 1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+ | | InChIKey | YQNRVGJCPCNMKT-LFVJCYFKSA-N | | SMILES | Oc1c(CC=C)cccc1\C=N\NC(=O)CN2CCN(CC2)Cc3ccccc3 |
| Description | PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2 Sensitizes cancer cells to various chemotherapeutic agents.3 | | Uses | PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM. | | Biological Activity | Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively). | | storage | +4°C | | References | [1] KARSON S PUTT. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy[J]. Nature chemical biology, 2006, 2 10: 543-550. DOI:10.1038/nchembio814
[2] QUINN P. PETERSON . PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition[J]. Journal of Molecular Biology, 2009, 388 1: Pages 144-158. DOI:10.1016/j.jmb.2009.03.003
[3] RACHEL C. BOTHAM. Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics[J]. ACS Central Science, 2016, 2 8: 545-559. DOI:10.1021/acscentsci.6b00165 |
| | PAC1 Preparation Products And Raw materials |
|