- NARINGENIN CHALCONE
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- $6.00 / 1KG
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2020-03-10
- CAS:73692-50-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg, 10kg ,50kg
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| | NARINGENIN CHALCONE Basic information |
| Product Name: | NARINGENIN CHALCONE | | Synonyms: | ISOSALIPURPOL;2',4',6',4-TETRAHYDROXYCHALCONE;NARINGENIN CHALCONE;C06561;NARINGENIN CHALCONE(cis and trans Mix)(RG);Naringein chalcone;(2E)-3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-2-propen-1-one;4,2',4',6'-Tetrahydroxychalcone | | CAS: | 73692-50-9 | | MF: | C15H12O5 | | MW: | 272.25 | | EINECS: | | | Product Categories: | | | Mol File: | 73692-50-9.mol |  |
| | NARINGENIN CHALCONE Chemical Properties |
| Melting point | 173-174℃ | | Boiling point | 538.7±50.0 °C(Predicted) | | density | 1.483±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMF:15.0(Max Conc. mg/mL);55.0(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);36.0(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.6(Max Conc. mM) | | form | A solid | | pka | 6.82±0.40(Predicted) | | color | Light yellow to orange | | InChI | InChI=1S/C15H12O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-8,16-17,19-20H | | InChIKey | YQHMWTPYORBCMF-UHFFFAOYSA-N | | SMILES | C(C1=C(O)C=C(O)C=C1O)(=O)C=CC1=CC=C(O)C=C1 | | LogP | 2.826 (est) |
| | NARINGENIN CHALCONE Usage And Synthesis |
| Chemical Properties | Soluble in organic solvents such as methanol, ethanol, and DMSO. | | Uses | Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties[1][2][3][4][5][6]. | | Definition | ChEBI: A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively. | | in vivo | Naringenin chalcone (0.8 mg/kg; p.o.; daily) reduces eosinophilic airway inflammation, airway hyperresponsiveness, suppressed Th2 cytokine production by splenic CD4+ T cells, and slightly reduced mucus overproduction in allergic asthmatic BALB/c mice[2].
Naringenin chalcone (5-80 mg/kg; 24 days) reduced tumor volume and tumor weight in U87MG human glioblastoma xenograft Balb/c nude mice[3].
Naringenin chalcone (p.o.) increases plasma adiponectin levels in diabetic mice[4].
Naringenin chalcone (0.02%; i.v.) inhibits the anaphylactic response to IgE-mediated passive cutaneous anaphylaxis in CD-1 mice[5].
Naringenin chalcone (20 mg/kg; p.o.; once) resultes in the detection of naringenin chalcone -2'-O-β-D-glucuronide in the plasma of male Sprague-Dawley rats[6].
| | References | [1] Hirai S, et al. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sci. 2007 Sep 29;81(16):1272-9. DOI:10.1016/j.lfs.2007.09.001
[2] Iwamura C, et al. Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergol Int. 2010 Mar;59(1):67-73. DOI:10.2332/allergolint.09-OA-0118
[3] Zhang S, et al. Anti-cancer effect of naringenin chalcone is mediated via the induction of autophagy, apoptosis and activation of PI3K/Akt signalling pathway. Bangladesh Journal of Pharmacology, 2016, 11(3): 684-690.
[4] Horiba T, et al. Naringenin chalcone improves adipocyte functions by enhancing adiponectin production. Mol Cell Endocrinol. 2010 Jul 29;323(2):208-14. DOI:10.1016/j.mce.2010.03.020
[5] Escribano-Ferrer E, et al. In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice. J Nat Prod. 2019 Feb 22;82(2):177-182. DOI:10.1021/acs.jnatprod.8b00366
[6] Yoshimura M, et al. Identification and quantification of metabolites of orally administered naringenin chalcone in rats. J Agric Food Chem. 2009 Jul 22;57(14):6432-7. DOI:10.1021/jf901137x |
| | NARINGENIN CHALCONE Preparation Products And Raw materials |
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