- 5-BROMO-2-METHOXYANILINE
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- $15.00 / 1KG
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2021-07-13
- CAS:6358-77-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 5-BROMO-2-METHOXYANILINE
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- $15.00 / 1KG
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2021-07-10
- CAS:6358-77-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 5-BROMO-2-METHOXYANILINE Basic information |
| Product Name: | 5-BROMO-2-METHOXYANILINE | | Synonyms: | 5-BROMO-2-METHOXYANILINE;5-bromo-2-methoxybenzenamine;2-amino-4-bromoanisole;5-bromo-o-anisidine;5-Bromo-2-methoxyaniline 98%;2-Amino-4-bromoanisole, 5-Bromo-o-anisidine;2-Methoxy-5-bromoaniline;4-Bromo-2-aminoanisole | | CAS: | 6358-77-6 | | MF: | C7H8BrNO | | MW: | 202.05 | | EINECS: | | | Product Categories: | Amines;blocks;Bromides | | Mol File: | 6358-77-6.mol |  |
| | 5-BROMO-2-METHOXYANILINE Chemical Properties |
| Melting point | 94-96°C | | Boiling point | 275℃ | | density | 1.531 | | Fp | 120℃ | | storage temp. | 2-8°C | | pka | 3.46±0.10(Predicted) | | form | powder to crystal | | color | Light yellow to Brown | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C7H8BrNO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,9H2,1H3 | | InChIKey | OPGNSNDTPPIYPG-UHFFFAOYSA-N | | SMILES | C1(N)=CC(Br)=CC=C1OC | | CAS DataBase Reference | 6358-77-6(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-33-43-22 | | Safety Statements | 26-33-36/37/39-45-36/37 | | RIDADR | UN2811 | | WGK Germany | 3 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 2921490090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Skin Sens. 1 |
| Provider | Language |
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ALFA
| English |
| | 5-BROMO-2-METHOXYANILINE Usage And Synthesis |
| Chemical Properties | Off-white powder | | Uses | 5-Bromo-2-methoxyaniline is used as a pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 5-bromo-2-methoxyaniline from 2-nitro-4-bromoanisole:
1. Preparation of Intermediate 11A: An ethanol (65 mL) solution of 4-bromo-1-methoxy-2-nitrobenzene (2.00 g, 8.62 mmol), zinc powder (5.64 g, 86.0 mmol), and ammonium chloride (4.61 g, 86.0 mmol) was stirred for 2 hours at room temperature.
2. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and filtered through diatomaceous earth (CELITE).
3. The filtrate was concentrated by evaporation to give Intermediate 11A (1.74 g, 100% yield) as an off-white solid.
4. Mass spectral analysis (LCMS-ESI) of Intermediate 11A showed m/z 202,204 ([M+H] , [M+2+H]) , and a retention time (RT) of 0.70 min (Method J). | | References | [1] Patent: WO2014/22343, 2014, A1. Location in patent: Paragraph 00169
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 5, p. 1357 - 1366
[3] Journal fuer Praktische Chemie (Leipzig), 1935, vol. <2> 143, p. 18,24
[4] Gazzetta Chimica Italiana, 1932, vol. 62, p. 51,54
[5] Justus Liebigs Annalen der Chemie, 1883, vol. 217, p. 44 |
| | 5-BROMO-2-METHOXYANILINE Preparation Products And Raw materials |
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