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| | 2-Amino-5-bromoisonicotinic acid Basic information |
| Product Name: | 2-Amino-5-bromoisonicotinic acid | | Synonyms: | 2-Amino-5-bromoisonicotinic acid;2-Amino-5-bromo-4-pyridinecarboxylic acid;2-aMino-5-broMopyridin-4-carboxylic acid;4-Pyridinecarboxylic acid,2-amino-5-bromo-;2-Amino-5-bromoisonicotinic;2-Amino-5-bromoisonicotinicaci;2-Amino-5-bromoisonicotinic acid ISO 9001：2015 REACH | | CAS: | 1000339-23-0 | | MF: | C6H5BrN2O2 | | MW: | 217.02 | | EINECS: | 202-303-5 | | Product Categories: | | | Mol File: | 1000339-23-0.mol |  |
| | 2-Amino-5-bromoisonicotinic acid Chemical Properties |
| Boiling point | 464.1±45.0 °C(Predicted) | | density | 1.909 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 1.16±0.10(Predicted) | | form | solid | | color | Yellow |
| HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 2-Amino-5-bromoisonicotinic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-amino-5-bromo-4-carboxylic acid pyridine from 2-amino-5-bromoisonicotinic acid methyl ester: 2-amino-5-bromoisonicotinic acid methyl ester (10.0 g, 43.28 mmol) and lithium hydroxide (LiOH, 5.46 g, 129.8 mmol) were reacted with 2-amino-5-bromo-4-carboxylic acid methyl ester (10.0 g, 43.28 mmol) and 2-amino-5-bromoisonicotinic acid methyl ester (10.0 g, 43.28 mmol) and lithium hydroxide (LiOH, 5.46 g, 129.8 mmol) in a water (100 mL) in a solvent mixture of tetrahydrofuran (THF, 400 mL), methanol (MeOH, 200 mL), and water (100 mL), and the reaction was stirred at 70 °C for 2 h under nitrogen (N2) protection. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and the pH was adjusted to 6 by dropwise addition of concentrated aqueous hydrochloric acid (HCl).Subsequently, the resulting suspension was filtered and the solid was dried under vacuum to afford pyridine 2-amino-5-bromo-4-carboxylic acid (7.8 g, 83% yield). The product was analyzed by liquid chromatography-mass spectrometry (LC-MS, ESI) and showed m/z 211 [M + H]+. | | References | [1] Patent: WO2012/58125, 2012, A1. Location in patent: Page/Page column 145 |
| | 2-Amino-5-bromoisonicotinic acid Preparation Products And Raw materials |
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