- 4-N-BOC-AMINOPHENOL
-
-
2026-07-06
- CAS:54840-15-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kgs
|
| | 4-N-BOC-AMINOPHENOL Basic information |
| Product Name: | 4-N-BOC-AMINOPHENOL | | Synonyms: | N-BOC-4-HYDROXY ANILINE;4-(BOC-AMINO)PHENOL;4-N-BOC-AMINOPHENOL;(4-HYDROXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, (4-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl 4-hydroxyphenylcarbamate;1,1-DiMethylethyl (4-hydroxyphenyl)carbaMate;tert-Butyl N-(4-hydroxyphenyl)carbamate | | CAS: | 54840-15-2 | | MF: | C11H15NO3 | | MW: | 209.24 | | EINECS: | | | Product Categories: | N-BOC | | Mol File: | 54840-15-2.mol |  |
| | 4-N-BOC-AMINOPHENOL Chemical Properties |
| Melting point | 143-147 °C(lit.) | | Boiling point | 288.7±23.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 10.13±0.26(Predicted) | | Appearance | White to off-white Solid | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C11H15NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h4-7,13H,1-3H3,(H,12,14) | | InChIKey | YRQMBQUMJFVZLF-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)NC1=CC=C(O)C=C1 | | CAS DataBase Reference | 54840-15-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-43 | | Safety Statements | 26-36-36/37 | | WGK Germany | 3 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-N-BOC-AMINOPHENOL Usage And Synthesis |
| Uses | 4-(Boc-amino)phenol, is used to protect amine in the solid phase synthesis of peptides, used to produce [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-carbamic acid tert-butyl ester at ambient temperature. This reaction will need reagent imidazole and solvent dimethylformamide, CH2Cl2. | | Synthesis | General procedure for the synthesis of oxycarbonyloxy-4-hydroxyaniline from di-tert-butyl dicarbonate and 4-aminophenol: Di-tert-butyl dicarbonate (24.07 g, 110.3 mmol) was slowly added to a methanol (200 mL) solution containing 4-aminophenol (10.97 g, 100.5 mmol) and triethylamine (30 mL). The reaction mixture was stirred at room temperature (22°C) for 14 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The residue was dissolved in ethyl acetate (250 mL) and extracted with 0.25N aqueous hydrochloric acid (100 mL). The organic phase was separated and washed sequentially with saturated aqueous ammonium chloride solution (3 x 50 mL) and dried over anhydrous sodium sulfate. Finally, the solvent was removed by rotary evaporation to give the white solid product oxocarbonyl-4-hydroxyaniline (20.91 g, 100% yield, ESI-MS (m/z) 208.1 [M-H]-). | | References | [1] Patent: EP1609789, 2005, A1. Location in patent: Page/Page column 12
[2] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[3] Chemical Communications, 2013, vol. 49, # 51, p. 5757 - 5759
[4] Organic Letters, 2016, vol. 18, # 21, p. 5728 - 5731
[5] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 962 - 966 |
| | 4-N-BOC-AMINOPHENOL Preparation Products And Raw materials |
|