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5-BroMo-4-fluoropyridin-2-aMine manufacturers
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| | 5-BroMo-4-fluoropyridin-2-aMine Basic information |
| Product Name: | 5-BroMo-4-fluoropyridin-2-aMine | | Synonyms: | 5-BroMo-4-fluoropyridin-2-aMine;2-aMino-5-broMo-4-fluoropyridine;5-Bromo-4-fluoro-pyridin-2-ylamine;5-bromo-2-amino-4-fluoropyridine;5-Bromo-4-fluoro-2-pyridinamine;152966;5-bromo-4-fluoropyridine-2-amine;2-Pyridinamine, 5-bromo-4-fluoro- | | CAS: | 944401-69-8 | | MF: | C5H4BrFN2 | | MW: | 191 | | EINECS: | | | Product Categories: | | | Mol File: | 944401-69-8.mol |  |
| | 5-BroMo-4-fluoropyridin-2-aMine Chemical Properties |
| Boiling point | 233.6±35.0 °C(Predicted) | | density | 1.813±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 4.31±0.24(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C5H4BrFN2/c6-3-2-9-5(8)1-4(3)7/h1-2H,(H2,8,9) | | InChIKey | GGHBRLQYBZMEPV-UHFFFAOYSA-N | | SMILES | C1(N)=NC=C(Br)C(F)=C1 |
| | 5-BroMo-4-fluoropyridin-2-aMine Usage And Synthesis |
| Uses | 5-BroMo-4-fluoropyridin-2-amine is a pyridine organic compound used in pharmaceutical synthesis and experiments.
| | Synthesis | A solution of 2-amino-4-fluoropyridine (75.0 g, 0.67 mol) in anhydrous acetonitrile (700 mL) was cooled in an ice-water bath under stirring conditions. Subsequently, N-bromosuccinimide (122.8 g, 0.69 mol) was added in batches. The reaction mixture was stirred continuously for 1 hour at room temperature. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was washed thoroughly with water (3 x 300 mL) and then dissolved with acetonitrile and again subjected to vacuum evaporation to finally obtain 5-bromo-2-amino-4-fluoropyridine as an off-white solid (124 g, 97% yield). | | References | [1] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 108
[2] Patent: WO2015/86526, 2015, A1. Location in patent: Page/Page column 110
[3] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 719 - 724
[4] Patent: WO2018/68283, 2018, A1. Location in patent: Paragraph 00252
[5] Patent: WO2018/68282, 2018, A1. Location in patent: Paragraph 00241 |
| | 5-BroMo-4-fluoropyridin-2-aMine Preparation Products And Raw materials |
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