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- N3-PEG2-Br
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2026-07-24
- CAS:530151-56-5
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
- Azido-PEG2-Br
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-
2025-06-07
- CAS:530151-56-5
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Bromo-PEG2-azide Basic information |
| Product Name: | Bromo-PEG2-azide | | Synonyms: | Azido-PEG2-Br;Bromo-PEG2-azide;Azido-PEG3-bromide;Br-PEG2-N3;1-(2-Azidoethoxy)-2-(2-bromoethoxy)ethane;N3-PEG2-CH2CH2Br;Bromo-PEG2-C2-azide;N3-PEG2-CH2CH2Br/Ethane, 1-(2-azidoethoxy)-2-(2-bromoethoxy)- | | CAS: | 530151-56-5 | | MF: | C6H12BrN3O2 | | MW: | 238.08238 | | EINECS: | | | Product Categories: | peg | | Mol File: | 530151-56-5.mol |  |
| | Bromo-PEG2-azide Chemical Properties |
| storage temp. | -20°C, stored under nitrogen | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow | | InChI | InChI=1S/C6H12BrN3O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-6H2 | | InChIKey | QZCKRLVDTQCBFT-UHFFFAOYSA-N | | SMILES | C(N=[N+]=[N-])COCCOCCBr |
| | Bromo-PEG2-azide Usage And Synthesis |
| Description | Bromo-PEG2-azide is a heterobifunctional crosslinking reagent.. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The bromide (Br) is a good leaving group for nucleophilic substitution. | | Biological Activity | Bromo-PEG2-C2-azide is a non-degradable ADC linker for the synthesis of antibody drug conjugates (ADCs),it is also a PEG-based PROTAC linker that can be used for PROTAC synthesis. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | target | | Non-cleavable < span> | PEGs | |
| | Bromo-PEG2-azide Preparation Products And Raw materials |
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