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- Bis-PEG7-NHS ester
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-
2025-06-07
- CAS:1334170-02-3
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | alpha, oMega-DisucciniMidyl hexaethylene glycol Basic information |
| Product Name: | alpha, oMega-DisucciniMidyl hexaethylene glycol | | Synonyms: | alpha, oMega-DisucciniMidyl hexaethylene glycol;NHS-PEG6-NHS;α,ω-disuccinimidyl hexaethylene glycol;4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid, 1,25-bis(2,5-dioxo-1-pyrrolidinyl) ester;Bis-dPEG7-NHS ester;Di-NHS Ester-PEG7;(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate;Bis-PEG7-NHS ester bis- | | CAS: | 1334170-02-3 | | MF: | C26H40N2O15 | | MW: | 620.6 | | EINECS: | | | Product Categories: | Homobifunctional PEG | | Mol File: | 1334170-02-3.mol |  |
| | alpha, oMega-DisucciniMidyl hexaethylene glycol Chemical Properties |
| storage temp. | Storage temp. -20°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Viscous Liquid | | color | Colorless to light yellow |
| | alpha, oMega-DisucciniMidyl hexaethylene glycol Usage And Synthesis |
| Description | Bis-PEG7-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | | Biological Activity | Bis-PEG7-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | target | | Cleavable | PEGs | Alkyl/ether | | | IC 50 | Cleavable Linker; PEGs; Alkyl/ether | | References | [1] Mahendra Persaud Deonarai, et al. Biological materials and uses thereof. WO2016046574A1 |
| | alpha, oMega-DisucciniMidyl hexaethylene glycol Preparation Products And Raw materials |
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