TCO-PEG4-NHS ester manufacturers
|
| | TCO-PEG4-NHS ester Basic information |
| Product Name: | TCO-PEG4-NHS ester | | Synonyms: | (4E)-TCO-PEG4-NHS ester;TCO-PEG4-NHS ester;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester;(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;2,5-dioxopyrrolidin-1-yl (Z)-1-(cyclooct-4-en-1-yloxy)-1-oxo-6,9,12,15-tetraoxa-2-azaoctadecan-18-oate;(E/Z)-TCO-PEG4-NHS ester | | CAS: | 1613439-69-2 | | MF: | C24H38N2O10 | | MW: | 514.57 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1613439-69-2.mol |  |
| | TCO-PEG4-NHS ester Chemical Properties |
| density | 1.23±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 11.95±0.46(Predicted) | | form | Oil | | color | Colorless to light yellow | | InChI | InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1- | | InChIKey | ZKPMRASGLDBKPF-UPHRSURJSA-N | | SMILES | C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6| |
| | TCO-PEG4-NHS ester Usage And Synthesis |
| Description | TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition | | Biological Activity | TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target |
| | TCO-PEG4-NHS ester Preparation Products And Raw materials |
|
|
Tag:TCO-PEG4-NHS ester(1613439-69-2)
Related Product Information
|
|
BDP fl-PEG4-(4E)-TCO
Gly-PEG3-(4E)-TCO
(4E)-TCO-PEG3-amine
(2E)-TCO-PNB ester
(4E)-TCO-PEG4-DBCO
(4E)-TCO-amine
TCO-PEG4-Acid
trans-Cyclooctene-maleimide
Sulfo-Cy5-(4E)-TCO
(4E)-TCO-PEG4-amine
TCO-PEG3-Amine
TCO-carbonate
TCO/E- active ester (p-NPE) / equatorial
|
According to the laws, regulations and policies related to "patent products", the sale of this product is prohibited!
ChemicalBook prompt
The patent owner or licensee of the product has not released any relevant information for the time being.
|