5'-Bromo-2'-hydroxy-3'-nitroacetophenone

5'-Bromo-2'-hydroxy-3'-nitroacetophenone Suppliers list

Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:	4006356688 18621169109
Email:	market03@meryer.com

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

5'-Bromo-2'-hydroxy-3'-nitroacetophenone Basic information

Product Name:	5'-Bromo-2'-hydroxy-3'-nitroacetophenone
Synonyms:	1-(5-BROMO-2-HYDROXY-3-NITROPHENYL)ETHANONE;3-BROMO-6-HYDROXY-5-NITRO ACETOPHENONE;5-BROMO-2-HYDROXY-3-NITROACETOPHENONE;JRH-01018, 1-(5-Bromo-2-hydroxy-3-nitrophenyl)ethanone, 97%;5'-Bromo-2'-hydroxy-3'-nitroacetophenone >;Ethanone, 1-(5-bromo-2-hydroxy-3-nitrophenyl)-;5'-Bromo-2'-hydroxy-3'-nitroacetophenone;5′-Bromo-2′-hydroxy-3′-nitroacetophenone, CAS 70978-54-0
CAS:	70978-54-0
MF:	C8H6BrNO4
MW:	260.04
EINECS:
Product Categories:	Aromatic Acetophenones & Derivatives (substituted);Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks
Mol File:	70978-54-0.mol

5'-Bromo-2'-hydroxy-3'-nitroacetophenone Chemical Properties

Melting point	129-132 °C(lit.)
Boiling point	272.9℃
density	1.763
Fp	118.9℃
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	6.47±0.38(Predicted)
color	Light yellow to Yellow to Orange
InChI	1S/C8H6BrNO4/c1-4(11)6-2-5(9)3-7(8(6)12)10(13)14/h2-3,12H,1H3
InChIKey	CLNIBJASCGZXHH-UHFFFAOYSA-N
SMILES	CC(=O)c1cc(Br)cc(c1O)[N+]([O-])=O
CAS DataBase Reference	70978-54-0(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

5'-Bromo-2'-hydroxy-3'-nitroacetophenone Usage And Synthesis

Uses	5'-Bromo-2'-hydroxy-3'-nitroacetophenone is used as a chemical reagent in the synthesis of amides and benzoxazoles directly using a sulfate catalyst and microwaves. 1-(5-Bromo-2-hydroxy-3-nitrophen yl)ethanone is used in studies involving HIV-1 integrase inhibitors.
Preparation	Preparation by nitration of 5-bromo-2-hydroxyacetophenone in refluxing carbon tetrachloride (88%).
Synthesis	1450-75-5 70978-54-0 1. Synthesis of 5-bromo-2-hydroxy-3-nitroacetophenone To a solution of 5-bromo-2-hydroxyacetophenone (23.7 g, 0.110 mol) in carbon tetrachloride (90 mL) was slowly added concentrated nitric acid (17.2 mL). The reaction mixture was stirred at 75 °C for 50 min and subsequently cooled to room temperature. The precipitated solid was collected by filtration and washed with cold carbon tetrachloride. After vacuum drying, 20.9 g of the target product 5-bromo-2-hydroxy-3-nitroacetophenone was obtained as a light yellow solid in 73% yield. 1H NMR (300 MHz, CDCl3) δ: 2.73 (s, 3H), 8.14 (d, 1H), 8.31 (d, 1H), 12.92 (s, 1H).
References	[1] Patent: US5990142, 1999, A [2] Patent: EP1391451, 2004, A1. Location in patent: Page 113 [3] Patent: WO2017/221002, 2017, A1. Location in patent: Page/Page column 92

5'-Bromo-2'-hydroxy-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials	5-Bromo-2-hydroxyacetophenone-->Nitric acid-->Carbon tetrachloride
Preparation Products	1-(3-amino-5-bromo-2-hydroxyphenyl)ethanone

Tag:5'-Bromo-2'-hydroxy-3'-nitroacetophenone(70978-54-0) Related Product Information

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