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| | FMOC-4-AMINOBENZOIC ACID Basic information |
| Product Name: | FMOC-4-AMINOBENZOIC ACID | | Synonyms: | FMOC-P-ABZ-OH;FMOC-4-AMINOBENZOIC ACID;4-(FMOC-AMINO)BENZOIC ACID;4-(9-FLUORENYLMETHYLOXYCARBONYL)AMINO-BENZOIC ACID;N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-4-AMINOBENZOIC ACID;N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-P-AMINOBENZOIC ACID;N-ALPHA-FMOC-P-AMINOBENZOIC ACID;N-FMOC-4-AMINOBENZOIC ACID | | CAS: | 185116-43-2 | | MF: | C22H17NO4 | | MW: | 359.37 | | EINECS: | | | Product Categories: | Unusual Amino Acids;Amino Acids;FMOC | | Mol File: | 185116-43-2.mol |  |
| | FMOC-4-AMINOBENZOIC ACID Chemical Properties |
| Melting point | ~277 °C (dec.) | | Boiling point | 544.9±33.0 °C(Predicted) | | density | 1.352±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.29±0.10(Predicted) | | form | powder | | Appearance | White to off-white Solid | | BRN | 7722986 | | Major Application | peptide synthesis | | InChI | 1S/C22H17NO4/c24-21(25)14-9-11-15(12-10-14)23-22(26)27-13-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-12,20H,13H2,(H,23,26)(H,24,25) | | InChIKey | VGSYYBSAOANSLR-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccc(NC(=O)OCC2c3ccccc3-c4ccccc24)cc1 | | CAS DataBase Reference | 185116-43-2(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10 | | HS Code | 2924 29 70 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids |
| | FMOC-4-AMINOBENZOIC ACID Usage And Synthesis |
| Chemical Properties | White powder | | Uses | Fmoc-4-aminobenzoic acid is used in the improved rapid synthesis of oligo(benzamide) block copolymers. | | reaction suitability | reaction type: Fmoc solid-phase peptide synthesis | | Synthesis | Under an inert atmosphere, p-aminobenzoic acid (10 g, 73 mmol) was dissolved in anhydrous N-methylpyrrolidone (NMP, 50 mL). Subsequently, a solution of anhydrous NMP (50 mL) of 9-fluorenylmethyl chloroformate (Fmoc-Cl, 18.9 g, 73 mmol) was slowly added dropwise. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the mixture was slowly poured into 400 mL of water to precipitate the product. The colorless precipitate was collected by filtration and washed with plenty of water. Finally, the product was dried under vacuum at 120 °C to afford N-Fmoc-p-aminobenzoic acid (24.8 g, 94% yield). The melting point of the product was 215 °C (decomposition). Nuclear magnetic resonance hydrogen spectrum (1H-NMR, 300 MHz, DMSO-d6): δ 4.33 (t, J = 6.25 Hz, 1H), 4.54 (d, J = 6.25 Hz, 2H), 7.33-7.45 (m, 4H), 7.57 (d, J = 7.35 Hz, 2H), 7.76 (d, J = 7.35 Hz, 2H), and 7.89 (m, 4H), 10.08 (s, 1H), 12.69 (s, 1H). NMR carbon spectrum (13C-NMR and DEPT, 300 MHz, DMSO-d6): δ 46.61 (CH2), 65.83 (CH), 117.5 (CH), 120.22 (CH), 124.48 (C), 125.14 (CH), 127.17 (CH), 127.74 (CH), 130.48 ( CH), 140.86 (C), 143.31 (C), 143.74 (C), 153.31 (C), 167.03 (C). Infrared spectra (IR, ν, cm-1): 3344, 2970, 2887, 2660, 2544, 1709, 1673, 1610, 1592, 1526, 1511, 1411, 1311, 1282, 1221, 1052, 850, 736. reversed-phase high performance liquid chromatography (RP-HPLC) retention time: 26.6 Minutes. Mass spectrometry (FD-MS): m/z (%) = 359.1 (100), 360.1 (17.4); calculated value [C22H17NO4] = 359.1. | | References | [1] Tetrahedron Letters, 2013, vol. 54, # 8, p. 753 - 756
[2] Chemical Communications, 2013, vol. 49, # 40, p. 4555 - 4557
[3] Journal of Chemical Research, Miniprint, 1998, # 10, p. 2736 - 2753
[4] Chemical Communications, 2014, vol. 50, # 14, p. 1691 - 1693 |
| | FMOC-4-AMINOBENZOIC ACID Preparation Products And Raw materials |
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