| Company Name: |
Ascent Scientific |
| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
TFLLR-NH2 manufacturers
- TFLLR-NH2 2TFA
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- $47.00
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2026-08-14
- CAS:
- Purity: 99.56%
- Supply Ability: 10g
- TFLLR-NH2
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2025-04-04
- CAS:197794-83-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- TFLLR-NH2
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- $7.00
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2020-02-14
- CAS: 197794-83-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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| | TFLLR-NH2 Basic information |
| Product Name: | TFLLR-NH2 | | Synonyms: | H-THR-PHE-LEU-LEU-ARG-NH2;THR-PHE-LEU-LEU-ARG-NH2;THROMBIN RECEPTOR (PAR-1), HYBRIDE HUMAN-XENOPE;TFLLR-AMIDE;TFLLR-NH2;(Thr1)-TRAP-5 amide;TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist;(2S)-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide | | CAS: | 197794-83-5 | | MF: | C31H53N9O6 | | MW: | 647.81 | | EINECS: | | | Product Categories: | Proteinase-activated receptor (PAR);Peptide Receptors | | Mol File: | 197794-83-5.mol |  |
| | TFLLR-NH2 Chemical Properties |
| density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | pka | 12.10±0.45(Predicted) | | form | Powder | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | Thr-Phe-Leu-Leu-Arg-NH2 |
| | TFLLR-NH2 Usage And Synthesis |
| Uses | TFLLR-NH2 is a PAR-1 activator. | | in vivo | Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1h and completely by 5h. In wild-type but not PAR1/ mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist[1]. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM[3]. | | IC 50 | PAR1: 1.9 μM (EC50) | | storage | -20°C |
| | TFLLR-NH2 Preparation Products And Raw materials |
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