- Trifluoroacetamide
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- $1.00 / 1KG
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2026-03-20
- CAS:354-38-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Trifluoroacetamide
-
- $20.60 / 1KG
-
2025-05-26
- CAS:354-38-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5000kg
- Trifluoroacetamide
-
- $10.00 / 1kg
-
2025-05-23
- CAS:354-38-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20 ton
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| | Trifluoroacetamide Basic information |
| | Trifluoroacetamide Chemical Properties |
| Melting point | 65-70 °C (lit.) | | Boiling point | 162.5 °C (lit.) | | bulk density | 960kg/m3 | | density | 1.4176 (estimate) | | Fp | 162-164°C | | storage temp. | Store below +30°C. | | solubility | 460 g/L (20°C) | | pka | 12.33±0.50(Predicted) | | form | Crystalline Powder or Crystals | | color | White to pale yellow or beige | | PH | 3.6 (460g/l, H2O, 23℃) | | Water Solubility | 460 g/L (20 ºC) | | BRN | 1753625 | | InChI | 1S/C2H2F3NO/c3-2(4,5)1(6)7/h(H2,6,7) | | InChIKey | NRKYWOKHZRQRJR-UHFFFAOYSA-N | | SMILES | NC(=O)C(F)(F)F | | LogP | 0.725 at 23℃ and pH4.83 | | Dissociation constant | 0 at 23℃ | | CAS DataBase Reference | 354-38-1(CAS DataBase Reference) | | NIST Chemistry Reference | Acetamide, 2,2,2-trifluoro-(354-38-1) | | EPA Substance Registry System | Acetamide, 2,2,2-trifluoro- (354-38-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | 1759 | | WGK Germany | 3 | | Hazard Note | Harmful/Irritant | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29241900 | | Storage Class | 13 - Non Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Trifluoroacetamide Usage And Synthesis |
| Chemical Properties | white to pale yellow or beige crystalline powder | | Uses | 2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups. | | Application | Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies. | | Preparation | One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292 | | General Description | Trifluoroacetamide is a good quencher of tryptophan fluorescence. | | Synthesis | Example 5: Synthesis of the blocking isomer trifluoroacetamide 3a
The block trans isomer 2a (0.93 g, 1.84 mmol, 503.4 g/mol) as a sulfate was dissolved in 15 mL of ethanol. Under argon protection, triethylamine (1.8 mL, 13 mmol) and ethyl trifluoroacetate (2.2 mL, 18 mmol) were slowly added (Figure 2a). The reaction mixture was stirred for 2.5 h at room temperature. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure. The resulting residue was dissolved in 300 mL of ethyl acetate and washed sequentially with 2 x 50 mL of 5% hydrochloric acid solution. The organic phase was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford block-transfer isomerized trifluoroacetamide 3a as an orange solid (0.92 g, 100% yield, 501.4 g/mol).
1H NMR (methanol-d4) δ 8.35 (1H, d); 8.15 (1H, d); 7.80 (1H, s); 6.82 (1H, s); 6.65 (4H, m); 4.82 (2H, s). | | References | [1] Patent: US6448407, 2002, B1
[2] Journal of the American Chemical Society, 1943, vol. 65, p. 1459
[3] Journal of Organic Chemistry, 1959, vol. 24, p. 1256,1258
[4] Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1922, vol. <5>8, p. 346 |
| | Trifluoroacetamide Preparation Products And Raw materials |
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