- 2,5-Dichloropyridine
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- $0.00 / 20kg
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2026-02-02
- CAS:16110-09-1
- Min. Order: 1kg
- Purity: 99%min
- Supply Ability: 100kgs
- 2,5-Dichloropyridine
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- $0.00 / 25KG
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2025-12-01
- CAS:16110-09-1
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 10000KGS
- 2,5-Dichloropyridine
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- $1.10 / 1g
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2025-11-18
- CAS:16110-09-1
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
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| | 2,5-Dichloropyridine Basic information | | Uses |
| Product Name: | 2,5-Dichloropyridine | | Synonyms: | 2,5-Dichloropyridine, 98% 5GR;2,5- twochlorine pyridine;2,5-Dichiloropyridine;2,5-Chloro pyridine;2,5-dichloro-pyridin;2,5-DICHLORPYRIDINE;2,5-Dichloropyridine97%;Dichloropyridine | | CAS: | 16110-09-1 | | MF: | C5H3Cl2N | | MW: | 147.99 | | EINECS: | 240-278-2 | | Product Categories: | Chlorinated heterocyclic series;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Chloropyridines;Halopyridines;Boronic Acid;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridine;pyridine derivative;Building Blocks;C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;alkyl chloride;bc0001 | | Mol File: | 16110-09-1.mol |  |
| | 2,5-Dichloropyridine Chemical Properties |
| Melting point | 59-62 °C (lit.) | | Boiling point | 190-191 °C | | density | 1.5159 (rough estimate) | | refractive index | 1.5500 (estimate) | | Fp | 112 °C | | storage temp. | Inert atmosphere,Room Temperature | | pka | -2.25±0.10(Predicted) | | form | Crystalline Solid | | color | White to slightly yellow | | Water Solubility | insoluble | | BRN | 108886 | | InChI | InChI=1S/C5H3Cl2N/c6-4-1-2-5(7)8-3-4/h1-3H | | InChIKey | GCTFDMFLLBCLPF-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=C(Cl)C=C1 | | CAS DataBase Reference | 16110-09-1(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-37/39-36 | | RIDADR | UN2811 | | WGK Germany | 3 | | RTECS | US8225000 | | Hazard Note | Harmful | | HazardClass | IRRITANT | | HazardClass | 6.1 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2,5-Dichloropyridine Usage And Synthesis |
| Uses | 2,5-Dichloropyridine is a reagent used in chemical synthesis. It has been used to synthesize 4-benzodiazepine-2,5 diones as Hdm2 antagonists and inhibitors of ERK protein kinase. | | Chemical Properties | white to slightly yellow crystalline solid | | Uses | 2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst. | | Synthesis Reference(s) | Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514 | | General Description | 2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst. | | Synthesis | General procedure for the synthesis of 2,5-dichloropyridine from 2,5-dibromopyridine: Catalyst 1 (10 mol%), 2,5-dibromopyridine (1.0 mmol), tetramethylammonium chloride (Me4NCl, 2.0 mmol), and ethanol (EtOH, 2.0 mL) were added to a Schlenk tube under nitrogen protection. Schlenk tubes were sealed using polytetrafluoroethylene (Teflon) valves and the reaction mixture was stirred at 100 °C. The reaction process was monitored by gas chromatography (GC) analysis. After completion of the reaction, the solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent ratio petroleum ether/ethyl acetate = 10:1) to give 2,5-dichloropyridine. The yield of the product was determined by high-resolution gas chromatography-mass spectrometry (GC-MS) analysis and the structure was confirmed by comparing its physical properties and spectral data with known compounds. | | References | [1] Applied Catalysis A: General, 2014, vol. 472, p. 178 - 183
[2] Chemical Communications, 2012, vol. 48, # 76, p. 9468 - 9470 |
| | 2,5-Dichloropyridine Preparation Products And Raw materials |
| Raw materials | Sulfuric acid-->Dichloromethane-->Sodium sulfate-->Sodium chloride-->3-Chloroperoxybenzoic acid-->Trimethylamine-->Benzenesulfonyl chloride-->3-Chloropyridine-->3-CHLOROPYRIDINE N-OXIDE-->3,4-Dichloropyridine-->2,3-Dichloropyridine | | Preparation Products | 2,5-DICHLORO-4-FORMYLPYRIDINE-->2,5-Dichloroisonicotinic acid-->2-Bromo-5-chloropyridine-->5-Chloropyridine-2-thiol-->5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID-->2,5-DICHLORO-3-IODOPYRIDINE-->2,5-Dichloro-4-iodopyridine-->5-Chloropyridine-2-carboxylic acid-->4-Piperidinol, 1-[6-(5'-chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]- |
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