2-Methoxyestradiol

‌2-Methoxyestradiol | Oral-Active Antiangiogenic Agent & Endogenous Metabolite | ≥99% Purity‌ 💊🔬

🌟 ‌Product Overview‌

2-Methoxyestradiol is a ‌naturally occurring estrogen metabolite‌ with potent antitumor and antiangiogenic properties‌12. It inhibits tumor growth by suppressing hypoxia-inducible factor-1α (HIF-1α) and inducing cancer cell apoptosis‌15. Widely used in oncology research and drug development, it also serves as a reference standard in metabolic disorder studies‌23.

✅ ‌Key Advantages‌

🧪 ‌Applications‌

• ‌Anticancer Drug Development‌

  : Targets breast, prostate, and ovarian cancers via HIF-1α inhibition‌15.

• ‌Angiogenesis Research‌

  : Suppresses tumor vascularization in preclinical models‌12.

• ‌Metabolic Studies‌

  : Analyzed as an endogenous biomarker for estrogen metabolism‌23.

• ‌Neuroprotection‌

  : Investigated for mitigating oxidative stress in neurodegenerative diseases‌45.

📜 ‌Quality Certifications‌

• ‌GMP Compliance‌

  : Manufactured in ISO 9001-certified facilities‌24.

• ‌Batch-Specific COA‌

  : Includes NMR, FTIR, and mass spectrometry validation‌12.

• ‌Residual Solvents‌

  : <10 ppm (meets ICH Q3C guidelines)‌24.

📈 ‌Market Trends‌

The ‌global anticancer drug market‌ is projected to reach ‌$300B by 2030‌, driven by demand for targeted therapies‌6. Angiogenesis inhibitors like 2-Methoxyestradiol account for ‌18% of oncology pipeline candidates‌, reflecting their therapeutic potential‌25.