N-Nitroso Desmethyl Sildenafil NEW

N-Nitroso Desmethyl Sildenafil

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E-mail: anna@molcoo.com

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• Product Information

• Product Number: N031028

• English Name: N-Nitroso Acarbose

• English Alias: N-((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-(((2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxy-2-methyltetrahydro-2H-pyran-3-yl)-N-((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)nitrous amide

• CAS Number: None

• Molecular Formula: C₂₅H₄₂N₂O₁₉

• Molecular Weight: 674.6

• Advantages

• As a nitroso derivative impurity of Acarbose, this compound has the following advantages:
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• Well-defined and distinct structure: A complex glycoside containing nitroso (-N=O) group, multiple pyran rings, and cyclohexenyl moiety, differing from Acarbose by nitroso substitution on the amino group. It can be accurately identified by techniques such as HPLC-UV or LC-MS, providing a specific marker for impurity detection;

• High stability and traceability: The N-nitrosamine structure is relatively stable under acidic conditions. As a product of amino group oxidation during Acarbose storage or production, it directly reflects the degree of oxidative degradation, improving the accuracy of quality tracing;

• Suitable for carbohydrate analysis: The strong polarity from multiple hydroxyl groups and specific absorption of nitroso group enable compatibility with carbohydrate detection systems, allowing trace analysis via HPLC-UV or MS without complex sample pretreatment.

• Applications

• Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify N-Nitroso Acarbose in Acarbose APIs and formulations, ensuring residual nitroso impurities from storage or production meet quality standards;

• Stability testing: Assessing the oxidative degradation trend of Acarbose formulations under various storage conditions (e.g., temperature, humidity) by monitoring impurity levels to support shelf-life determination;

• Degradation pathway analysis: Investigating the oxidative breakdown mechanism of Acarbose in aerobic environments, clarifying the formation route of nitroso impurities to optimize antioxidant production processes.

• Background Description

• Acarbose is an α-glucosidase inhibitor used in type 2 diabetes treatment, with a complex carbohydrate structure containing oxidizable amino groups. During storage (especially when exposed to air or light), amino groups may undergo oxidation to form nitroso derivatives, namely N-Nitroso Acarbose. N-nitrosamines are potentially genotoxic and carcinogenic, making their control a critical aspect of Acarbose quality assurance and safety evaluation.

• Research Status

• Current research focuses on:
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• Detection method advancement: Using UPLC-MS/MS with optimized parameters for nitroso group fragmentation to achieve ultra-trace detection (detection limits down to ppb level);

• Oxidation kinetics: Studying impurity formation rates under varying pH and oxygen concentrations to elucidate key factors driving amino group oxidation in Acarbose;

• Toxicological profiling: Evaluating genotoxic potential through in vitro assays (e.g., Ames test) to establish scientifically based impurity limits;

• Stabilization strategies: Developing oxygen-impermeable packaging or incorporating natural antioxidants (e.g., vitamin C) to minimize formation of this nitroso impurity in Acarbose products.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com