TH588 NEW
| Price | $57 | $83 | $128 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: TH588 | CAS No.: 1609960-31-7 |
| Purity: 99.52% | Supply Ability: 10g |
| Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | TH588 |
| Description | TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells. |
| In vitro | In mice carrying xenografts with the BRAFV600E mutation, TH588 (30 mg/kg, subcutaneously) reduces tumor growth rates. Additionally, in mice bearing SW480 colon or MCF7 breast cancer xenografts, TH588 (30 mg/kg, subcutaneously) inhibits MTH1, resulting in decreased tumor growth. |
| In vivo | TH588 induces DNA damage in U2OS cells, triggering ATM-p53-mediated DNA repair and apoptotic responses. It exhibits selective cytotoxicity towards U2OS and other cancer cell lines while showing minimal toxicity towards several primary or immortalized cell lines. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 88.33 mg/mL (299.25 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.78 mM), Sonication is recommended. |
| Keywords | TH-588 | TH588 | TH 588 | RNASynthesis | RNA Synthesis | MTH1 | Inhibitor | inhibit | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis |
| Inhibitors Related | 5-Fluorouracil | Adenine hemisulfate | Erythromycin thiocyanate | Guanidine hydrochloride | Hexane-1,6-diol | 1,4-Naphthoquinone | Adenine | Vidarabine | Carbazole | Thymidine | Docosanoic acid | Usnic Acid |
| Related Compound Libraries | Highly Selective Inhibitor Library | DNA Damage & Repair Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Multi-Target Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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