- TH588
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- $57.00 / 5mg
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2026-04-21
- CAS:1609960-31-7
- Min. Order:
- Purity: 99.52%
- Supply Ability: 10g
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| Product Name: | TH588 | | Synonyms: | N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;TH588(TH-588);6-(2,3-dichlorophenyl)-N4-cyclopropylpyrimidine-2,4-diamine;TH 588;TH-588;TH588;CS-1701;TH588, >98% | | CAS: | 1609960-31-7 | | MF: | C13H12Cl2N4 | | MW: | 295.17 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1609960-31-7.mol |  |
| | TH588 Chemical Properties |
| Boiling point | 545.7±60.0 °C(Predicted) | | density | 1.505±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 5 mg/ml). | | form | powder | | pka | 5.90±0.10(Predicted) | | color | white to light brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChI | 1S/C13H12Cl2N4.ClH/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10;/h1-3,6-7H,4-5H2,(H3,16,17,18,19);1H | | InChIKey | FBHMEHNWFXCSKE-UHFFFAOYSA-N | | SMILES | ClC1=CC=CC(C2=NC(N)=NC(NC3CC3)=C2)=C1Cl.Cl |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | TH588 Usage And Synthesis |
| Description | TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50= 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Activein vitroandin vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3Conversely, TH588 has been also shown to decrease osteosarcoma cell viability, impair cell cycle, and increase apoptosis via an MTH1-dependent pathway.4 | | Uses | TH 588 acts as a novel potent and selective permeable inhibitor of the nudix hydrolase MTH1 protein. It acts as a good tool to show the non-oncogene addiction concept to anti-cancer treatments. | | Biochem/physiol Actions | TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. MTH1 hydrolyzes oxidized purine nucleoside triphosphates that might otherwise be incorporated into DNA/RNA and contribute to DNA damage. MTH1 removal of oxidized nucleotides that result from increased levels of reactive oxygen species (ROS) in fast-proliferating cancer cells helps protect cancer cells from proliferative stress and prevent cancer cell death. TH588 is considered a new target for cancer therapy. TH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts. | | in vivo | TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1]. | Animal Model: | 5-6 weeks female SCID mice (SW480 xenograft cancer model)[1] | | Dosage: | 30 mg/kg | | Administration: | Subcutaneous injection; once daily for 35 days | | Result: | Reduced tumour growth in SW480 xenograft cancer model. |
| | storage | Store at -20°C | | References | [1] HELGE GAD. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool[J]. Nature, 2014, 508 7495: 215-221. DOI:10.1038/nature13181
[2] ALESSIA PETROCCHI. Identification of potent and selective MTH1 inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 6: Pages 1503-1507. DOI:10.1016/j.bmcl.2016.02.026
[3] JASON G. KETTLE*. Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival[J]. Journal of Medicinal Chemistry, 2016, 59 6: 2346-2361. DOI:10.1021/acs.jmedchem.5b01760
[4] BRICE MOUKENGUE. TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.[J]. EBioMedicine, 2020, 53: 102704. DOI:10.1016/j.ebiom.2020.102704 |
| | TH588 Preparation Products And Raw materials |
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