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ChemicalBook >> CAS DataBase List >> GSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII

$44 - $1180
Product name: GSK-3β Inhibitor XVIII
CAS: 1139875-74-3
MF: C20H20ClN5OS
MW: 413.92
EINECS:
MDL Number:MFCD32671859
Synonyms:GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;GSK3β-IN-1a;GSK3β Inhibitor XVIII;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;GSK-3β inhibitor 8;(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

Price17 Properties Safety Information Description

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aablocks
ACHEMBLOCK
AK Scientific
Arctom
Cayman Chemical
ChemScene
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1mg
5mg
10mg
25mg
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100mg

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging1mg
Price$87
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging5mg
Price$179
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging10mg
Price$257
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging25mg
Price$431
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging50mg
Price$603
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging100mg
Price$808
Updated2026-05-30
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ManufacturerACHEMBLOCK
Product numberAD285566
Product descriptionGSK-3 98%
Packaging100MG
Price$1180
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberAD285566
Product descriptionGSK-3 98%
Packaging25MG
Price$615
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberAD285566
Product descriptionGSK-3 98%
Packaging5MG
Price$235
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number3559DG
Product description(2-Chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging25mg
Price$927
Updated2021-12-16
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ManufacturerArctom
Product numberHY-120902
Product descriptionGSK-3Î² inhibitor 8 98.16%
Packaging1mg
Price$98
Updated2026-05-26
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ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging5mg
Price$193
Updated2024-03-01
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ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging10mg
Price$341
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging1mg
Price$44
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging25mg
Price$745
Updated2024-03-01
Buy

ManufacturerChemScene
Product numberCS-0079556
Product descriptionGSK-3β inhibitor 8 98.16%
Packaging1mg
Price$112
Updated2026-06-04
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	1mg	$87	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	5mg	$179	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	10mg	$257	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	25mg	$431	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	50mg	$603	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	100mg	$808	2026-05-30	Buy
ACHEMBLOCK	AD285566	GSK-3 98%	100MG	$1180	2026-05-27	Buy
ACHEMBLOCK	AD285566	GSK-3 98%	25MG	$615	2026-05-27	Buy
ACHEMBLOCK	AD285566	GSK-3 98%	5MG	$235	2026-05-27	Buy
AK Scientific	3559DG	(2-Chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone	25mg	$927	2021-12-16	Buy
Arctom	HY-120902	GSK-3Î² inhibitor 8 98.16%	1mg	$98	2026-05-26	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	5mg	$193	2024-03-01	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	10mg	$341	2024-03-01	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	1mg	$44	2024-03-01	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	25mg	$745	2024-03-01	Buy
ChemScene	CS-0079556	GSK-3β inhibitor 8 98.16%	1mg	$112	2026-06-04	Buy

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Properties

Boiling point :632.3±65.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble
pka :6+-.0.10(Predicted)
form :White solid
color :White to off-white

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC₅₀ = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC₅₀ = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC₅₀ = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

GSK-3β inhibitor 8 CAS:1139875-74-3

Ningbo Chaoming Biotechnology Co., Ltd BOC Sciences Shanghai EFE Biological Technology Co., Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. Jinan Jiuli Biotechnology Co. , Ltd. TargetMol Chemicals Inc. Nantong QuanYi Biotechnology Co., Ltd Nantong Hanfang Biotechnology Co. , Ltd. Aikon International Limited

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GSK-3β Inhibitor XVIII

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