1-Benzyl-3-piperidinol synthesis
- Product Name:1-Benzyl-3-piperidinol
- CAS Number:14813-01-5
- Molecular formula:C12H17NO
- Molecular Weight:191.27
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14813-01-5
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Yield:14813-01-5 342.6 g
Reaction Conditions:
with methanol;sodium tetrahydroborate at 25; for 4 h;Reflux;
Steps:
2 Preparation of 1-benzyl-3-piperidinol
Methanol (10 L) and 1-benzyl-3-hydroxypyridinium bromide (500 g) were added to the reaction flask. Sodium borohydride (215 g) was added in portions at a temperature not exceeding 25 ° C. After the addition was completed, it was heated to reflux. After reacting for 4 hours, the reaction was completed, and the mixture was cooled to 0 to 10 ° C. Hydrochloric acid was added dropwise, and the pH was adjusted to 8. The solvent was concentrated under reduced pressure, dissolved in ethyl acetate and saturated brine, and the mixture was separated. In the product twice, The combined ethyl acetate phases were dried over anhydrous sodium sulfate and filtered. Concentrated to dryness afforded 342.6 g of pale yellow oil.
References:
CN104529872,2018,B Location in patent:Paragraph 0035-0037
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