1-Bromo-4-cyclohexylbenzene synthesis
- Product Name:1-Bromo-4-cyclohexylbenzene
- CAS Number:25109-28-8
- Molecular formula:C12H15Br
- Molecular Weight:239.15
108-85-0
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5467-74-3
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$8.00/1g
25109-28-8
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$12.00/1g
Yield:25109-28-8 87%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);tetrabutylammomium bromide;potassium carbonate in water;toluene at 80; for 4 h;Inert atmosphere;
Steps:
1 Step 1:
Under a nitrogen atmosphere, add 2.45g (15mmol) of 1-bromocyclohexane, 3.02g (15mmol) of p-bromobenzeneboronic acid,A mixture of 0.17 g (0.15 mmol) tetrakis (triphenylphosphine) palladium, 0.05 g (0.15 mmol) tetrabutylammonium bromide and 4.15 g (30 mmol) potassium carbonate was added to a 100 mL three-necked flask,20mL / 5mL of toluene / water mixed solvent was added to the flask, heated to 80 ° C with stirring and reacted for 4 hours,The reaction was stopped, and the reaction solution was extracted with ethyl acetate. The organic phase was dried with magnesium sulfate and concentrated under reduced pressure to remove the solvent.The obtained solid was recrystallized with n-heptane to obtain compound 61-1 (compound 61-1) (3.13 g, yield 87%).
References:
CN111004207,2020,A Location in patent:Paragraph 0209-0210
827-52-1
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25109-28-8
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1605-17-0
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25109-28-8
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589-87-7
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931-51-1
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25109-28-8
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108-86-1
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108-93-0
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25109-28-8
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59734-92-8
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