12401 synthesis
- Product Name:12401
- CAS Number:1254102-12-9
- Molecular formula:C18H16N4O3
- Molecular Weight:336.35
948893-91-2
4 suppliers
inquiry
1254102-12-9
2 suppliers
inquiry
Yield:1254102-12-9 92%
Reaction Conditions:
with tetrabutyl ammonium fluoride in tetrahydrofuran at 20;
Steps:
5 Intermediate 5: (R)-5-(2-Azido-1-hydroxyethyl)-8-(benzyloxy)quinolin-2(1H)-one
A 1.0 M (THF) solution of TBAF (0.443 mL, 0.443 mmol) was added to a stirring solution of Intermediate 1 (200 mg, 0.443 mmol) in THF (4 mL) at rt. The resulting mixture was stirred over night then concentrated. Chromatography (1:3, Hexanes/EtOAc) afforded the title compound (137 mg, 92%) as an off-white solid. ES/MS calcd. for C18H17N4O3+ 337.1. Found m/z=337.2 (M+H)+.
References:
US2011/275622,2011,A1 Location in patent:Paragraph 0284
530084-79-8
160 suppliers
$16.00/100mg
1254102-12-9
2 suppliers
inquiry
93609-84-8
120 suppliers
$6.00/100mg
1254102-12-9
2 suppliers
inquiry
100331-89-3
217 suppliers
$70.00/10mg
1254102-12-9
2 suppliers
inquiry
1127-45-3
241 suppliers
$6.00/1g
1254102-12-9
2 suppliers
inquiry