tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate synthesis
- Product Name:tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate
- CAS Number:188624-94-4
- Molecular formula:C11H19NO2
- Molecular Weight:197.27
![7-azabicyclo[2.2.1]heptane](/CAS/GIF/279-40-3.gif)
279-40-3
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24424-99-5
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Yield:188624-94-4 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 4 h;
Steps:
1.1 Step 1: Preparation of compound 1b
Dissolve 7-azabicyclo[2.2.1]heptane 1a (4g, 41.1mmol) in 300mL of dichloromethane at room temperature, then add triethylamine (6.3g, 61.8mmol) and di-tert-butyl dicarbonate ( 13.5g, 61.8mmol). The reaction was stirred at room temperature for 4 hours, extracted with dichloromethane (100mL×3), and the organic phases were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered to remove the desiccant, and the filtrate was concentrated under reduced pressure and subjected to silica gel column chromatography. Purified with an eluent system (petroleum ether/ethyl acetate=20:1) to obtain a colorless oily product 1b (10 g, yield: 100%).
References:
CN112574221,2021,A Location in patent:Paragraph 0084-0090
111300-06-2
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177545-89-0
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24424-99-5
796 suppliers
$13.50/25G
![7-Azabicyclo[2,2,1]heptane hydrochloride](/CAS/GIF/27514-07-4.gif)
27514-07-4
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177545-89-0
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91230-16-9
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