4-HYDROXYCYCLOHEXANONE synthesis
- Product Name:4-HYDROXYCYCLOHEXANONE
- CAS Number:13482-22-9
- Molecular formula:C6H10O2
- Molecular Weight:114.14
556-48-9
317 suppliers
$6.00/5g
13482-22-9
198 suppliers
$8.00/250mg
Yield:13482-22-9 91%
Reaction Conditions:
with sodium bromate;ammonium cerium (IV) nitrate in water;acetonitrile for 2.5 h;Reflux;
Steps:
1 Step 1: 4-hydroxycyclohexanone
Cerium (IV) ammonium nitrate (45.4 g, 82.85 mmol) and sodium bromate (125 g, 0.828 mol) were added to a solution of 1 ,4-cyclohexanediol (commercially available from Sigma-Aldrich, Milwaukee, WI, 278 g, 2.393 mol) in ACN (2.7 L) and water (1.15 L). The resulting mixture was heated at reflux for 2.5 hours and then cooled to room temperature. The resulting solution was extracted with chloroform (1 L x 3), and the combined organic extracts were dried, filtered and concentrated to afford 4-hydroxycyclohexanone (245 g, 91%). m/z (ESI) 1 15 (M+H)+.
References:
AMGEN INC.;BREGMAN, Howard;BUCHANAN, John, L.;CHAKKA, Nagasree;DIMAURO, Erin;GUNAYDIN, Hakan;GUZMAN PEREZ, Angel;HUA, Zihao;HUANG, Hongbing;HUANG, Xin;MARTIN, Matthew, W.;PATEL, Vinod WO2013/134079, 2013, A1 Location in patent:Paragraph 0219-0220
123-31-9
854 suppliers
$13.00/25g
13482-22-9
198 suppliers
$8.00/250mg
![1,4-Dioxaspiro[4.5]decan-8-one](/CAS/GIF/4746-97-8.gif)
4746-97-8
490 suppliers
$5.00/1g
13482-22-9
198 suppliers
$8.00/250mg
637-88-7
340 suppliers
$5.00/1g
13482-22-9
198 suppliers
$8.00/250mg
![1,4-DIOXA-SPIRO[4.5]DECAN-8-OL](/CAS/GIF/22428-87-1.gif)
22428-87-1
200 suppliers
$6.00/1g
13482-22-9
198 suppliers
$8.00/250mg