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1,4-Cyclohexanedione

1,4-Cyclohexanedione Structure
1,4-Cyclohexanedione structure
CAS No.
637-88-7
Chemical Name:
1,4-Cyclohexanedione
Synonyms
CHD;Cyclohexane-1,4-dione;CYCLOHEXANEDIONE;1,4-Cyclohexadione;Tetrahydroquinone;1,4-CYCHEXANEDIONE;1,4-CYCLOHEXANDIONE;1,4-cyclohexanedion;1,4-Cyclohexanedione;1,4-Dioxocyclohexane
CBNumber:
CB7138205
Molecular Formula:
C6H8O2
Molecular Weight:
112.13
MDL Number:
MFCD00001606
MOL File:
637-88-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-29 20:13:11
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1,4-Cyclohexanedione Properties

Melting point 77-78.5 °C (lit.)
Boiling point 112 °C (19.5026 mmHg)
Density 1.0861
refractive index 1.4570 (estimate)
Flash point 132 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in methanol and ethanol.
form Crystalline Powder or Flakes
color Light yellow to yellow or beige
BRN 774152
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChI 1S/C6H8O2/c7-5-1-2-6(8)4-3-5/h1-4H2
InChIKey DCZFGQYXRKMVFG-UHFFFAOYSA-N
SMILES O=C1CCC(=O)CC1
LogP -0.910 (est)
CAS DataBase Reference 637-88-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII BJS27Z99AM
NIST Chemistry Reference 1,4-Cyclohexanedione(637-88-7)
EPA Substance Registry System 1,4-Cyclohexanedione (637-88-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Safety Statements  22-24/25
WGK Germany  3
F  8
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29142900
Storage Class 11 - Combustible Solids
NFPA 704
1
1 0

1,4-Cyclohexanedione price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 125423 1,4-Cyclohexanedione 98% 637-88-7 10g $66.4 2026-04-30 Buy
Sigma-Aldrich 125423 1,4-Cyclohexanedione 98% 637-88-7 50g $122 2026-04-30 Buy
TCI Chemical C0730 1,4-Cyclohexanedione >98.0%(GC) 637-88-7 25g $47 2026-04-30 Buy
TCI Chemical C0730 1,4-Cyclohexanedione >98.0%(GC) 637-88-7 500g $458 2026-04-30 Buy
Usbiological 558461 chd PurifiedbyProteinGaffinitychromatography. 50ug $509 2026-06-03 Buy
Product number Packaging Price Buy
125423 10g $66.4 Buy
125423 50g $122 Buy
C0730 25g $47 Buy
C0730 500g $458 Buy
558461 50ug $509 Buy

1,4-Cyclohexanedione Chemical Properties,Uses,Production

Chemical Properties

tan or yellow crystalline powder

Uses

1,4-Cyclohexanedione is used in the preparation of 1,4 benzoquinone and bromoorganics. It is also used to study the influence of visible light on the bromate-1,4-cyclohexanedione-ferroin oscillating reaction. It plays a vital role in pharmaceuticals, plant growth regulator and as a conducting material.

Definition

ChEBI: 1,4-Cyclohexanedione is a cyclohexanedione with oxo substituents at positions 1 and 4.

Preparation

Synthesis of 1,4-cyclohexanedione: put diethyl succinylsuccinate into a flask, add a mixture of concentrated sulfuric acid, water and ethanol, reflux in oil solution for 5 days, cool, and neutralize to pH with ammonia water = 8; then extract 4 times with chloroform, and recover the chloroform to obtain the crude product; then the crude product is subjected to vacuum distillation, and the distillate is poured into cold petroleum ether, filtered, and air-dried to obtain 1,4-cyclohexanedi Ketone Products.

Synthesis Reference(s)

Synthesis, p. 165, 1981 DOI: 10.1055/s-1981-29377

General Description

1,4-Cyclohexanedione(CHD) undergoes uncatalyzed oscillatory reactions during oxidation by acidic bromate in nitric acid and sulphuric acid solution. It reacts with acidic bromate to form 1,4-dihydroxybenzene which on further oxidation and bromination yields 1,4-benzoquinone and bromoorganics.

Pharmacology

The cyclohexanedione (CHD) herbicides inhibit fatty acid synthesis in plants by interfering with the activity of the enzyme Acetyl-Coenzyme A Carboxylase (ACCase). ACCase-inhibiting herbicides provide excellent control of grass weeds in dicotyledonous and some grass crops. A less-sensitive ACCase mediates the intrinsic resistance of dicotyledonous plants to the AOPP and CHD herbicides (34,35). Although grasses are target species of this group of herbicides, not all are equally affected, and sensitivity differences can occur between varieties or even within a genus.

1,4-Cyclohexanedione synthesis

108-93-0
637-88-7
Synthesis of 1,4-Cyclohexanedione from Cyclohexanol

1,4-Cyclohexanedione Preparation Products And Raw materials

Raw materials

dilute sulphuric acid Diethyl succinosuccinate Diethyl succinate 1,4-Dioxaspiro[4.5]decan-8-one 1,4-Cyclohexanedione bis(ethylene ketal)
1,4-Dioxa-spiro[4.5]decan-8-ol

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Preparation Products

Homogentisic acid gamma-lactone trans-1,4-Diaminocyclohexane trans-4-Aminocyclohexanol Pentacene N-Methoxy-N-methylacetamide
1,4-Cyclohexanediol 1,2-Cyclohexanediol 4-Hydroxycyclohexanone Mecarbinate 2-Methyl-1,3-cyclopentanedione
1 4-Bis(diphenylamino)benzene 10-Phenyl-10H-phenothiazine 4-Methoxycyclohexanol 5,7-Dihydro-indolo[2,3-b]carbazole

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1,4-Cyclohexanedione Suppliers

Global( 434)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Maison Chemical Co.,Ltd. 155-11852758; 18408670720 ruby@maisonchem.com.cn China 687 58
Hebei Wenjing United Technology Co. LTD 18633031353 17734561860 16021353@qq.com China 62 58
Xi 'an billiton biological technology co., LTD 029-88764766 chen.zeshan@xatuochao.com China 521 58
XIANAONARUNNEWMATERIALCo.,Ltd 029-81509060 13629280593 2074901304@qq.com China 185 58
BTC Pharmaceutical CO. Ltd +86-15716293042 15716293042 info@btcpharm.com China 823 55
Wuhan EnTai Technology Development Co,.Ltd 86-27-82330560 2536851935@qq.com China 346 69
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Supplier Advantage
Hebei Maison Chemical Co.,Ltd. 58
Hebei Wenjing United Technology Co. LTD 58
Xi 'an billiton biological technology co., LTD 58
XIANAONARUNNEWMATERIALCo.,Ltd 58
BTC Pharmaceutical CO. Ltd 55
Wuhan EnTai Technology Development Co,.Ltd 69
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
future industrial shanghai co., ltd 65

View Lastest Price from 1,4-Cyclohexanedione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-Cyclohexanedione pictures 2026-06-30 1,4-Cyclohexanedione
637-88-7
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1,4-Cyclohexanedione pictures 2026-05-28 1,4-Cyclohexanedione
637-88-7
 $9.00 1KG 99.8% 100tons Hebei Chuanghai Biotechnology Co,.LTD
1,4-Cyclohexanedione pictures 2026-03-20 1,4-Cyclohexanedione
637-88-7
 1KG 99% 100 MT Hebei Chuanghai Biotechnology Co., Ltd

1,4-Cyclohexanedione Spectrum

1,4-Cyclohexanedione(637-88-7)MS1,4-Cyclohexanedione(637-88-7)1HNMR1,4-Cyclohexanedione(637-88-7)13CNMR1,4-Cyclohexanedione(637-88-7)IR11,4-Cyclohexanedione(637-88-7)IR21,4-Cyclohexanedione(637-88-7)Raman

637-88-7(1,4-Cyclohexanedione )Related Search:

Cyclohexane 2,5-Hexanedione 2,5-dioxo-1,4-cyclohexanedicarboxylic acid dimethyl ester Diethyl succinosuccinate 1,3-Cyclohexanedione
1,2-Cyclohexanedione 4,4-DIMETHYL-1,3-CYCLOHEXANEDIONE Sulcotrione 1,4-Cyclohexanedione bis(ethylene ketal) 2-Methyl-1,3-cyclohexanedione
FEMA 3269 1,4-Cyclohexanedione mono(2,2-dimethyltrimethylene ketal) Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate 5-Phenylcyclohexane-1,3-dione 5-Isopropyl-1,3-cyclohexanedione
5-(2-Ethylthio propyl)-1,3-cyclohexanedione Dimedone CYCLOPENTADIENE-QUINONE (2:1)ADDUCT

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1,4-Dioxocyclohexane Tetrahydroquinone TETRAHYDRO-P-BENZOQUINONE Cyclohexan-1,4-dione 98% 1,4-CYCHEXANEDIONE Cyclohexan-1,4-dione 1,4-Cyclohexanedione,98% 1,4-CYCLOHEXANDIONE 1,4-TETRAHYDROQUINONE 1,4-CYCLOHEXANEDIONE, 98%1,4-CYCLOHEXANEDIONE, 98%1,4-CYCLOHEXANEDIONE, 98% 1,4-Cyclohexanedione 1,4-Cyclohexanedione, 98% 10GR 1,4-Cyclohexanedione, 98% 50GR 1,4-Cyclohexadione 1,4-CYCLOHEXANEDIONE FOR SYNTHESIS 1,4-cyclohexanedion 1,4-Cyclohexanedione Vetec(TM) reagent grade, 98% 1, 4 - ring adipic ketone 1,4-Cyclohexanedione > 637-88-7 1,4-Cyclohexanedione 1,4-Cyclohexanedione pure, 99% 1,4-Cyclohexanedione (8CI, 9CI, ACI) CHD CYCLOHEXANEDIONE Cyclohexane-1,4-dione 637-88-7 C3 to C6 Carbonyl Compounds Building Blocks Ketones Organic Building Blocks C3 to C6 Carbonyl Compounds Ketones Building Blocks C3 to C6 Carbonyl Compounds Chemical Synthesis Organic Building Blocks fine chemicals ketone Pharmaceutical Intermediate