trans-4-Hydroxy-L-proline methyl ester hydrochloride synthesis
- Product Name:trans-4-Hydroxy-L-proline methyl ester hydrochloride
- CAS Number:40216-83-9
- Molecular formula:C6H12ClNO3
- Molecular Weight:181.62
67-56-1
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13726-69-7
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40216-83-9
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$6.00/5g
Yield:40216-83-9 99%
Reaction Conditions:
with hydrogenchloride at 20; for 12 h;
Steps:
Compound 20r (2 g, 8.6 mmol) was taken up with a solution of HC1 (g) in methanol (4 M, 40 mL). The mixture was stirred at ambient temperature for 12 hrs. After that, the reaction mixture was concentrated under reduced pressure to afford compound 20s (1.6 g, yield 99%) as a white solid.
References:
INTERMUNE, INC.;BUCKMAN, Brad;NICHOLAS, John, B.;SEREBRYANY, Vladimir;SEIWERT, Scott, D. WO2012/37259, 2012, A1 Location in patent:Page/Page column 74
67-56-1
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$7.30/5ml-f
32968-78-8
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$16.00/100mg
40216-83-9
329 suppliers
$6.00/5g
74844-91-0
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$5.00/5g
40216-83-9
329 suppliers
$6.00/5g
