3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride synthesis
- Product Name:3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride
- CAS Number:4462-55-9
- Molecular formula:C11H6Cl3NO2
- Molecular Weight:290.53
3919-76-4
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$15.00/1g
4462-55-9
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$22.00/5g
Yield: 94%
Reaction Conditions:
with thionyl chloride;N,N-dimethyl-formamide at 60;
Steps:
32.3 Step 3, 3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazole-4-carbonyl chloride (23d)
To a 50 mL round-bottom flask was added 3-(2,6-dichlorophenyl)-5-methyl-l,2- oxazole-4-carboxylic acid 23c (600 mg, 2.21 mmol, 1.0 equiv.), thionyi chloride (10 mL), and a catalytic amount of Ν,Ν-dimethylformamide. The resulting mixture was stirred overnight at 60 °C and concentrated in vacuo to give 3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazole-4-carbonyl chloride 23d (600 mg, 94%) as colorless oil.
References:
ARDELYX, INC.;CHAO, Jianhua;JAIN, Rakesh;HU, Lily;LEWIS, Jason Gustaf;BARIBAULT, Helene;CALDWELL, Jeremy WO2018/39384, 2018, A1 Location in patent:Paragraph 00441
4402-83-9
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4462-55-9
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83-38-5
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$6.00/10g
4462-55-9
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6579-27-7
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$45.00/100mg
4462-55-9
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25185-95-9
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4462-55-9
179 suppliers
$22.00/5g