CarbaMic acid, (3-aMino-2,6-difluorophenyl)-, 1,1-diMethylethyl ester synthesis
- Product Name:CarbaMic acid, (3-aMino-2,6-difluorophenyl)-, 1,1-diMethylethyl ester
- CAS Number:535170-20-8
- Molecular formula:C11H14F2N2O2
- Molecular Weight:244.24
535170-17-3
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535170-20-8
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Yield:535170-20-8 86%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in methanol; for 15 h;
Steps:
1.3 Step 3: Preparation of tert-butyl-3-amino-2,6-difluorophenylcarbamate
After dissolving the tert-butyl-2,6-difluoro-3-nitrophenylcarbamate (1 g, 3.6 mmol) prepared at Step 2 in methanol solvent, palladium carbon (100 mg) was added and stirred under hydrogen pressure for 15 hours. After completing the reaction, filtering through celite, vacuum concentrating, and refining by means of column chromatography, 0.76 mg of the target compound, tert-butyl-3-amino-2,6-difluorophenylcarbamate (percentage yield: 86%), was obtained.1H NMR (400MHz, CDCl3) : δ 6.74 (m, 1H), 6. 59 (m, 1H), 5.95(bs, 1H), 3.62(bs, 2H), 1.51(s, 9H).
References:
EP2647637,2013,A2 Location in patent:Paragraph 0057
83141-10-0
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535170-20-8
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$31.00/100mg
260552-98-5
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535170-20-8
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385-00-2
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$5.00/5g
535170-20-8
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24424-99-5
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25892-09-5
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535170-20-8
24 suppliers
$31.00/100mg