4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER synthesis
- Product Name:4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
- CAS Number:655225-01-7
- Molecular formula:C11H21BrN2O2
- Molecular Weight:293.2
77279-24-4
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655225-01-7
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Yield: 83.7%
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in dichloromethane at 20;Cooling with ice;
Steps:
168.168-1 Example 168-1: Synthesis of tert-butyl 4-(2-bromomethyl)piperazine-1-carboxylate
Carbon tetrabromide (1.681 g, 5.07 mmol) was dissolved in dichloromethane (17 ml), cooled with ice.thereTertiary butyl 4- (2-hydroxyMethyl) piperazine-1-carboxylate (1.062 g, 4.61 mmol), triphenylphosphine (1.329 g, 5.07 mmol), and stirred overnight at room temperature was added dichloromethane (11 ml). After the reaction, the solvent was evaporated. The residue was purified by silica gel column chromatography (SNAP ULTRA 25 g, hexane / ethyl acetate) to give the title compound (1.131 g, 83.7%) as a yellow solid.
References:
Yakult Honsha Co., Ltd.;University of Occupational and Environmental Health;Ono, Masahiro;Kobayashi, Tsuneyuki;Yamazaki, Ryuta;Haibara, Hirotake;Nishiyama, Yukiko;Hokkyo, Atsuko;Nishiyama, Hiroyuki;Kurita, Akinobu;Matsuzaki, Ken;Kono, Kimitoshi;Izumi, Hiroto JP2016/124812, 2016, A Location in patent:Paragraph 0367
106-93-4
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57260-71-6
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655225-01-7
75 suppliers
$26.00/100mg
57260-71-6
748 suppliers
$5.00/5g
655225-01-7
75 suppliers
$26.00/100mg
24424-99-5
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655225-01-7
75 suppliers
$26.00/100mg
103-76-4
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$6.00/25g
655225-01-7
75 suppliers
$26.00/100mg