TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
- CAS No.
- 77279-24-4
- Chemical Name:
- TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
- Synonyms
- BUTTPARK 46\04-31;Boc-Piperazine-OH;BOC-N-(2-HYDROXYETHYL)PIPERAZINE;1-Boc-4-(2-hydroxyethyl)-piperazi;1-BOC-4-(2-HYDROXYETHYL)-PIPERAZINE;N-Boc-N’-(2-hydroxyethyl)-piperazine;1-Boc-4-(2-hydroxyethyl)piperazine 97%;N-BOC-Nzzhlxy-(2-hydroxyethyl)piperazine;tert-Butyl 4-(2-hydroxyethyl)piperazine-1-;4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
- CBNumber:
- CB8389646
- Molecular Formula:
- C11H22N2O3
- Molecular Weight:
- 230.3
- MDL Number:
- MFCD00728947
- MOL File:
- 77279-24-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Boc-4-(2-hydroxyethyl)piperazine 97% | 685909 | 5g | $130 |
| tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate min. 98.0 % | B6368 | 5G | $35 |
| tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate min. 98.0 % | B6368 | 25G | $104 |
| tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate | B943578 | 5g | $130 |
| tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate | B943578 | 1g | $45 |
| More product size | |||
| Melting point | 38-42 °C |
|---|---|
| Boiling point | 114°C 0,1mm |
| Density | 1.092±0.06 g/cm3(Predicted) |
| Flash point | 110 °C |
| storage temp. | 2-8°C |
| pka | 14.96±0.10(Predicted) |
| form | Solid |
| color | White to pale brown |
| InChI | InChI=1S/C11H22N2O3/c1-11(2,3)16-10(15)13-6-4-12(5-7-13)8-9-14/h14H,4-9H2,1-3H3 |
| InChIKey | VRXIOAYUQIITBU-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCN(CCO)CC1 |
| CAS DataBase Reference | 77279-24-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310+P330 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,N,T | |||||||||
| Risk Statements | 36/37/38-50-25 | |||||||||
| Safety Statements | 26-36/37/39-61-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933599590 | |||||||||
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 685909 | 1-Boc-4-(2-hydroxyethyl)piperazine 97% | 77279-24-4 | 5g | $130 | 2023-06-20 | Buy |
| TCI Chemical | B6368 | tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate min. 98.0 % | 77279-24-4 | 5G | $35 | 2026-03-19 | Buy |
| TCI Chemical | B6368 | tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate min. 98.0 % | 77279-24-4 | 25G | $104 | 2026-03-19 | Buy |
| TRC | B943578 | tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate | 77279-24-4 | 5g | $130 | 2021-12-16 | Buy |
| TRC | B943578 | tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate | 77279-24-4 | 1g | $45 | 2021-12-16 | Buy |
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Chemical Properties,Uses,Production
Uses
Boc-Piperazine-OH is a PROTAC Linker in SJ46420 (HY-168635)[1].
Synthesis
103-76-4
24424-99-5
77279-24-4
General procedure: synthesis of tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (57): 1-(2-hydroxyethyl)piperazine (3.0 g, 23.0 mmol) was dissolved in dry tetrahydrofuran (THF) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.5 g, 25.3 mmol) was slowly added to this solution. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was evaporated to half of the initial volume by rotary evaporator. The concentrated mixture was poured into deionized water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure to afford the light yellow oily product tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (5.3 g, quantitative yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.46 (s, 9H), 2.44-2.46 (m, 4H), 2.54-2.57 (m, 2H), 2.66 (m, J = 5.3 Hz, 1H), 3.42-3.45 (m, 4H), 3.62 (q, J = 5.3 Hz, 2H).
References
[1] Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. DOI:10.1038/s41467-024-52966-3
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
View Lastest Price from TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-05 | TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
77279-24-4
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
77279-24-4
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
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