BOC-MET-GLY-OH synthesis
- Product Name:BOC-MET-GLY-OH
- CAS Number:23446-03-9
- Molecular formula:C12H22N2O5S
- Molecular Weight:306.38
![Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl-, methyl ester](/CAS/20210111/GIF/68164-11-4.gif)
68164-11-4
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23446-03-9
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Yield:23446-03-9 87.2%
Reaction Conditions:
with methanol;sodium hydroxide at 20; for 3 h;
Steps:
5
General procedure: Compound 9a (2.6 g, 10 mmol) in 50 ml methanol was treatedwith 1 M NaOH (30 ml), and stirred for 3 h at room temperature.The solvent was evaporated in vacuum and the residue wasadjusted to PH 2-3 with 1 M HCl. The mixture was extracted 3times by EtOAc. The organic phase was dried over Na2SO4. Evaporationof EtOAc provided compound 10a. White solid: yield 92.4%,
References:
Zhang, Jian;Li, Xiaoyang;Jiang, Yuqi;Feng, Jinhong;Li, Xiaoguang;Zhang, Yingjie;Xu, Wenfang [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 11,p. 3055 - 3064]
![L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, 2,4,5-trichlorophenyl ester](/CAS/20210305/GIF/16948-13-3.gif)
![Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl-, 2-propenyl ester (9CI)](/CAS/20210305/GIF/358758-86-8.gif)
358758-86-8
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23446-03-9
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2488-15-5
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$10.00/1g
23446-03-9
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