Ethyl 4-bromophenylacetate synthesis
- Product Name:Ethyl 4-bromophenylacetate
- CAS Number:14062-25-0
- Molecular formula:C10H11BrO2
- Molecular Weight:243.1
1878-68-8
502 suppliers
$6.00/10g
14062-25-0
250 suppliers
$6.00/5g
Yield:14062-25-0 99%
Reaction Conditions:
with sulfuric acid in ethanol
Steps:
202.1 N-(2-fluorobenzyl)-4-[N'-[2-[3-[(1S)-1-aminoethyl]phenoxy]-4-chlorophenyl]-N'-[(2'-methoxybiphenyl-4-yl)acetyl]]aminobutylamide hydrochloride
(1) Concentrated sulfuric acid (10 ml) was added to an ethanol (300 ml) solution of 4-bromophenylacetic acid (25 g, 120 mmols), and heated under reflux for 15 hours. The reaction mixture was concentrated under reduced pressure, and the residue was poured into water with ice, and extracted with ethyl acetate. The extract was washed with water, and then dried with anhydrous magnesium sulfate. This was concentrated under reduced pressure to give an oil of ethyl 4-bromophenylacetate (28 g, 99%). 1H-NMR (CDCl3) δ: 1.25(3H,t,J=7.2Hz), 3.56(2H,s),
References:
Takeda Chemical Industries, Ltd. EP1123918, 2001, A1
64-17-5
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$10.00/50g
1878-68-8
502 suppliers
$6.00/10g
14062-25-0
250 suppliers
$6.00/5g
64-17-5
760 suppliers
$10.00/50g
201230-82-2
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106-38-7
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$14.00/5g
14062-25-0
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$6.00/5g
19213-72-0
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1878-68-8
502 suppliers
$6.00/10g
14062-25-0
250 suppliers
$6.00/5g