Glycopyrrolate synthesis
- Product Name:Glycopyrrolate
- CAS Number:596-51-0
- Molecular formula:C19H28BrNO3-
- Molecular Weight:398.33
74-83-9
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596-51-0
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Yield:596-51-0 144 g
Reaction Conditions:
in acetonitrile at -10 - 20; for 12 h;
Steps:
1.4; 1.5
260 g of intermediate III obtained in step 3 was dissolved by heating to 310 g of acetonitrile, cooled down to -10 DEG C, 167 g of methyl bromide was introduced, and the temperature was raised to room temperature for 12 hours.Filtration gave 311 g of crude glycopyrrolate; The crude glycopyrrolate was recrystallized from butanone to obtain 144 g of glycopyrrolate qualified product.The yield of the target product was 42.1% in one step, and the total yield was 36.1%. The purity of the product was >99.0% as determined by HPLC.
References:
CN107879962,2018,A Location in patent:Paragraph 0041; 0046
13220-33-2
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596-51-0
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