Maleimide-PEG4-NHS Ester synthesis
- Product Name:Maleimide-PEG4-NHS Ester
- CAS Number:756525-99-2
- Molecular formula:C22H31N3O11
- Molecular Weight:513.49
6066-82-6
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1263045-16-4
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756525-99-2
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$150.00/100 mg
Yield: 0.109 g
Reaction Conditions:
with 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
Steps:
Referring to the scheme of synthesis of Compound O, β-alanine was treated with maleic anhydride in DMF and the acid so obtained was reacted with N-hydroxysuccinimide (NHS) under DCC coupling to give NHS-ester. The BOC protective group in commercially available t-blc-N-amido-dPEG4-acid was removed by treatment with TFA to give the TFA salt of the amine, which was reacted with previously synthesized NHS ester. The carboxylic acid so obtained was isolated and was coupled with N-hydroxysuccinimide using EDCI to furnish NHS ester Compound O.
References:
BIOLLIANCE C.V.;ABGENOMICS INTERNATIONAL INC.;LIN, Rong-hwa;LIN, Shih-yao;HSIEH, Yu-chi;HUANG, Chiu-chen WO2014/100762, 2014, A1 Location in patent:Paragraph 240; 248
756525-91-4
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756525-99-2
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7423-55-4
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$6.00/250mg
756525-99-2
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55750-62-4
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$18.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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756525-99-2
106 suppliers
$150.00/100 mg
55750-62-4
255 suppliers
$18.00/250mg
756525-99-2
106 suppliers
$150.00/100 mg