Pitavastatin Methyl Ester synthesis
- Product Name:Pitavastatin Methyl Ester
- CAS Number:849811-78-5
- Molecular formula:C26H26FNO4
- Molecular Weight:435.49
32249-35-7
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Yield:-
Steps:
Multi-step reaction with 9 steps
1.1: tin(IV) chloride / toluene / 3 h / 15 °C / Inert atmosphere; Reflux
2.1: copper(I) bromide; tert.-butylnitrite / acetonitrile / 2.5 h / 15 - 40 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / toluene; hexane / 1 h / 0 - 20 °C / Inert atmosphere
4.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere
5.2: 0 - 20 °C / Inert atmosphere
6.1: hydrogenchloride / acetonitrile / 19 h / 0 - 20 °C
7.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 1.33 h / -78 °C
7.2: 3 h / 20 °C
8.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / dimethyl sulfoxide / 4 h / 70 °C / Inert atmosphere
9.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrakis(triphenylphosphine) palladium(0); sodium carbonate / dimethyl sulfoxide / 9 h / 90 °C / Inert atmosphere
References:
Yagi, Yusuke;Kimura, Hiroyuki;Arimitsu, Kenji;Ono, Masahiro;Maeda, Kazuya;Kusuhara, Hiroyuki;Kajimoto, Tetsuya;Sugiyama, Yuichi;Saji, Hideo [Organic and Biomolecular Chemistry,2015,vol. 13,# 4,p. 1113 - 1121]
![Heptanedioic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-, 1-methyl 7-(phenylmethyl) ester, (3R)-](/CAS/20200611/GIF/1343494-43-8.gif)
1343494-43-8
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1885-29-6
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![Heptanedioic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-, 1-methyl ester, (3R)-](/CAS/20200611/GIF/1343494-44-9.gif)
1343494-44-9
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849811-78-5
52 suppliers
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