TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE synthesis
- Product Name:TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE
- CAS Number:187283-17-6
- Molecular formula:C13H18BrNO2
- Molecular Weight:300.19
123986-64-1
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187283-17-6
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$16.00/100mg
Yield: 95%
Reaction Conditions:
with phosphorus tribromide in tetrahydrofuran at -78; for 2 h;
Steps:
91
A solution of 4-(N-t-Boc-aminomethyl)benzyl alcohol (250 mg, 1.1 mmol) in THF (5 mL) was treated with phosphorustribromide (30 uL, 0.32 mmol) at -78° C. for 2 h. After this period, the reaction was quenched with solid NaHCO3 (50 mg) and filtered to remove the solids and the filtrate was evaporated to give 4-(t-Boc-aminomethyl)benzyl bromide (300 mg, 95%).
References:
Eli Lilly and Company;Wayne State University;University of Hawaii US6680311, 2004, B1 Location in patent:Page/Page column 151
39895-56-2
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187283-17-6
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$16.00/100mg
874-89-5
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$6.00/250mg
187283-17-6
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24424-99-5
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187283-17-6
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$16.00/100mg
17201-43-3
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$6.00/5g
187283-17-6
91 suppliers
$16.00/100mg