| Identification | Back Directory | [Name]
Fluorescein-PEG2-Azide | [CAS]
1146195-72-3 | [Synonyms]
5-FITC-PEG2-azide
Fluorescein-PEG2-N3
Fluorescein-PEG2-Azide
Fluorescein-PEG8-Azide
Fluorescein-thiourea-PEG2-azide | [Molecular Formula]
C27H25N5O7S | [MDL Number]
MFCD32173718 | [MOL File]
1146195-72-3.mol | [Molecular Weight]
563.59 |
| Hazard Information | Back Directory | [Description]
Fluorescein-PEG2-azide is a green emitting fluorescent dye derivitative with excitation/emmission maximum 494/517 nm containing an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. | [Uses]
Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Fluorescein-thiourea-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Alfa Chemistry
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1-516-6625404 |
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https://www.alfa-chemistry.com |
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