| Identification | Back Directory | [Name]
Methylamino-PEG3-azide | [CAS]
1355197-57-7 | [Synonyms]
N3-PEG3-CH2CH2NHMe
Methylamino-PEG3-azide | [Molecular Formula]
C9H20N4O3 | [MDL Number]
MFCD29042356 | [MOL File]
1355197-57-7.mol | [Molecular Weight]
232.28 |
| Hazard Information | Back Directory | [Description]
Methylamino-PEG3-azide is a PEG linker containing an azide group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. | [Uses]
Methylamino-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methylamino-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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