| Identification | Back Directory | [Name]
Pyrene -PEG3-azide | [CAS]
1817735-36-6 | [Synonyms]
Pyrene-PEG3-N3
Pyrene -PEG3-azide
Pyrene-amido-PEG4-azide | [Molecular Formula]
C25H28N4O4 | [MDL Number]
MFCD29042350 | [MOL File]
1817735-36-6.mol | [Molecular Weight]
448.52 |
| Hazard Information | Back Directory | [Description]
Pyrene-PEG3-azide is a pyrene labeled PEG linker containing an azide group, which enables Click Chemistry labeling with any alkyne-bearing molecules and thus turns any molecule into pyrene-bearing probe. | [Uses]
Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Pyrene-amido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|