| Identification | Back Directory | [Name]
Ald-Ph-PEG4-t-butyl ester | [CAS]
1807518-64-4 | [Synonyms]
Ald-Ph-PEG4-Boc
CHO-Ph-PEG4-COOtBu
Ald-Ph-PEG4-COOtBu
DF-PEG4-CH2CH2COOtBu
CHO-Ph-CONH-PEG4-COOtBu
ALD-PH-PEG4-CH2CH2COOTBU
Ald-Ph-PEG4-t-butyl ester
tert-butyl 1-(4-formylphenyl)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
4,7,10,13-Tetraoxa-16-azaheptadecanoic acid, 17-(4-formylphenyl)-17-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C23H35NO8 | [MDL Number]
MFCD28950774 | [MOL File]
1807518-64-4.mol | [Molecular Weight]
453.53 |
| Chemical Properties | Back Directory | [Boiling point ]
606.4±55.0 °C(Predicted) | [density ]
1.129±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Viscous Liquid | [pka]
13.53±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Ald-Ph-PEG4-t-butyl ester contains a benzaldehyde group which can react with aminooxy (ONH2) bearing molecules. The t-butyl ester is a protecting group that can be removed under acidic conditions for further conjugation, PEG space improve aqueous solubility. | [Uses]
Ald-Ph-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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