| Identification | Back Directory | [Name]
Propargyl-PEG6-acid | [CAS]
1951438-84-8 | [Synonyms]
CAS_1951438-84-8
Propargyl-PEG6-acid
Propyne-PEG5-CH2CH2COOH
Propargyl-PEG5-CH2CH2COOH
4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid | [Molecular Formula]
C16H28O8 | [MDL Number]
MFCD28950778 | [MOL File]
1951438-84-8.mol | [Molecular Weight]
348.39 |
| Chemical Properties | Back Directory | [Boiling point ]
462.8±45.0 °C(Predicted) | [density ]
1.126±0.06 g/cm3(Predicted) | [refractive index ]
n/D 1.469 | [storage temp. ]
-20°C | [solubility ]
Soluble in Water | [form ]
liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18) | [InChIKey]
XRSJYQQOJNYUDV-UHFFFAOYSA-N | [SMILES]
OC(CCOCCOCCOCCOCCOCCOCC#C)=O |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG6-acid comprises propargyl and carboxylic acid functional groups. The acid group reacts with primary amines in the presence of activators (e.g. EDC, or HATU).The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The molecule has good solubility in aqueous environment. | [Uses]
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. | [reaction suitability]
reaction type: click chemistry
reagent type: cross-linking reagent | [IC 50]
Cleavable Linker; PEGs |
|
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|